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Andrey S. Shaw, M.D.

Head of the Division of Immunobiology and Investigator, Howard Hughes Medical Institute Professor of Pathology and Immunology, Washington University School of Medicine

Email: shawa6@gene.com

Dr. Andrey S. Shaw is a professor in the Department of Pathology and Immunology at Washington University in St. Louis, Missouri. He is the head of the Division of Immunobiology and an Investigator of the Howard Hughes Medical Institute. Dr. Shaw is a former editor of Molecular and Cellular Biology, a journal published by the American Society for Microbiology, and has served on the Immunology Program Steering Committee and the Curriculum Committee at Washington University Medical School. He is the recipient of the National Institutes of Health MERIT Award and numerous Distinguished Service Teaching Awards from the Washington University School of Medicine.

Dr. Shaw attended medical school at the Columbia University College of Physicians and Surgeons. After completing his residency in pathology at Yale-New Haven Hospital, he went on to complete a post-doctoral fellowship in the Department of Pathology and the Department of Cell Biology at Yale.

Dr. Shaw’s current work focuses on podocytes and the genetic defects that can compromise cell function in human patients. He’s already found that mutations which produce CD2AP protein deficiency can cause kidney disease, and he pursues other genes that may be involved.

Selected Publications
Malone AF, Phelan PJ, Hall G, Cetincelik U, Homstad A, Alonso AS, Jiang R, Lindsey TB, Wu G, Sparks MA, Smith SR, Webb NJ, Kalra PA, Adeyemo AA, Shaw AS, Conlon PJ, Jennette JC, Howell DN, Winn MP, Gbadegesin RA. Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis. Kidney Int. 2014 Sep 17.

Gbadegesin RA, Hall G, Adeyemo A, Hanke N, Tossidou I, Burchette J, Wu G, Homstad A, Sparks MA, Gomez J, Jiang R, Alonso A, Lavin P, Conlon P, Korstanje R, Stander MC, Shamsan G, Barua M, Spurney R, Singhal PC, Kopp JB, Haller H, Howell D, Pollak MR, Shaw AS, Schiffer M, Winn MP. Mutations in the Gene That Encodes the F-Actin Binding Protein Anillin Cause FSGS. J Am Soc Nephrol. 2014 Sep; 25(9):1991-2002.

Olaru F, Luo W, Suleiman H, St John PL, Ge L, Mezo AR, Shaw AS, Abrahamson DR, Miner JH, Borza DB. Neonatal Fc receptor promotes immune complex-mediated glomerular disease. J Am Soc Nephrol. 2014 May; 25(5):918-25.

Russo LM, Srivatsan S, Seaman M, Suleiman H, Shaw AS, Comper WD. Albuminuria associated with CD2AP knockout mice is primarily due to dysfunction of the renal degradation pathway processing of filtered albumin. FEBS Lett. 2013 Nov 15; 587(22):3738-41.

Suleiman H, Zhang L, Roth R, Heuser JE, Miner JH, Shaw AS, Dani A. Nanoscale protein architecture of the kidney glomerular basement membrane. Elife. 2013 Oct 8; 2:e01149.

Yu H, Suleiman H, Kim AH, Miner JH, Dani A, Shaw AS, Akilesh S. Rac1 activation in podocytes induces rapid foot process effacement and proteinuria. Mol Cell Biol. 2013 Dec; 33(23):4755-64.

Howard Hughes Medical Institute | Washington University School of Medicine

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