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Home / Managing RKD / Clinical Trials / APPRECIATE Study

APPRECIATE Study

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Brief Description

The purpose of this study is to learn more about the safety, tolerability, and effectiveness of AZD2373 and to better understand AMKD and associated health problems.

Trial Physician / Study Coordinator

Samer Diab Agha

Email
Estimated Enrollment

96

Estimated End Date

October, 2026

Trial is for people with

A diagnosis of Apolipoprotein L1 (APOL1)-Mediated Kidney Disease (AMKD) – this is checked via a blood sample during the Screening ...

Study Goal

AZD2373 leads to decrease in UACR in patients with AMKD who are homozygotes or compound heterozygotes for APOL1 high-risk genotypes ...

What is involved for the patient?

During the Screening and Run-in period (16-weeks) patients will be asked to allow researchers access to their medical history and the ...

About the drug or intervention

AZD2373 is being developed as a potential treatment for AMKD. It works by decreasing the production of the APOL1 protein. AZD2373 does ...

Find other locations for this trial:
Pompano Beach, FL

I'm Interested in this Trial

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Have you ever had a kidney transplant?*
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Disclaimer

By clicking the submit button, your information and results will be sent to the study coordinator. Submitting the form does not guarantee enrollment but helps determine potential eligibility and connects you with the study team. Please consult your healthcare provider before pursuing participation in any trial.

Frequently Asked Questions

Nephrotic Syndrome is not a disease itself, but rather a group of signs and symptoms that result from damage in the part of the kidney that filters blood (glomeruli).

Common symptoms include:

  • Foamy urine (called proteinuria) caused by protein “spilling” into the urine
  • Severe swelling in parts of the body, most noticeably around the eyes, hands, feet, and abdomen (called edema)
  • Weight gain due to a buildup of extra fluid
  • Fatigue
  • Loss of appetite
  • Low levels of protein in the blood (hypoalbuminemia)
  • Higher than normal fat and cholesterol levels in the blood (hyperlipidemia)

Nephrotic Syndrome can typically be diagnosed with a urine test.

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Nephrotic Syndrome can be “primary” or “secondary” in nature.

Diseases that affect only the kidneys are called primary causes of Nephrotic Syndrome. Doctors often call these diseases “idiopathic,” which means that they arise from an unknown cause. Some of these diseases include:

  • Minimal Change Disease (MCD) – most common in children
  • Focal Segmental Glomerulosclerosis (FSGS)
  • Membranous Nephropathy (MN) – most common in adults
  • IgA Nephropathy (IgAN)

Secondary Nephrotic Syndrome is caused by an underlying, systemic condition like diabetes, lupus, HIV, and others.

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Clinical studies are any studies that involve people. There are two main types: observational and interventional. In an observational trial, researchers track health outcomes over time in groups of participants to look for patterns that help us better understand a disease. In an interventional trial, participants receive specific interventions, which can include new treatments or behavorial changes (e.g., diet changes). To learn more about clinical research, please visit the NephCure website.

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