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C3G Awareness Day 2026
September 25th
Join NephCure in raising awareness, amplifying patient voices, and building a stronger future for everyone affected by C3 Glomerulopathy (C3G).
C3G is an ultra-rare kidney disease that can affect both children and adults. This C3G Awareness Day, learn more about C3G, connect with others in the community, explore recent treatment advances, and discover trusted resources and support.
Your Voice Matters
If you or someone you love is living with C3G, we want to hear from you. The people who live with C3G every day understand its challenges better than anyone. By sharing your experience, you can help NephCure better understand the needs and priorities of the C3G community and shape future programs, resources, events, and advocacy efforts.
Take our quick survey and help us build resources informed by the people who know C3G best.
take surveyUnderstanding C3G
Complement 3 Glomerulopathy (C3G) is a rare, chronic kidney disease that damages the glomeruli—the tiny filtering units in the kidneys that help remove toxins from the blood. Complement 3, or C3, is a protein that plays an important role in the body’s alternative complement system, which helps regulate the immune response. In people with C3G, the alternative complement system becomes overactive. This can cause inflammation and damage to the glomeruli, leading to blood in the urine (hematuria), protein in the urine (proteinuria), and chronic kidney damage over time. Approximately half of people with C3G progress to kidney failure within 10 to 15 years.
C3G at a Glance
C3G affects approximately 1 to 2 people out of every 1 million people in the United States. It can affect people of all ages but is often diagnosed during in people in their 20s and 30s. For approximately 10% to 25% of people with C3G, genetic changes in specific proteins are associated with the disease. Researchers continue to study what causes C3G in others.
Two Types of C3G
Dense Deposit Disease (DDD)
C3 Glomerulonephritis (C3GN)
Did You Know?
C3G is ultra-rare—but awareness can make a meaningful difference.
-C3G can affect both children and adults.
-Symptoms can resemble those of other kidney diseases, which can make diagnosis challenging.
-C3G is associated with abnormal activity in the complement system.
-C3G can recur even after a kidney transplant.
A Community of Strength: Every C3G Story Matters
Living with C3G looks different for everyone.
This C3G Awareness Day, we’re highlighting the voices of people who know the disease firsthand. Their stories reflect the challenges of navigating a rare diagnosis, and the strength, hope, and connection found within the C3G community.
Join the Live Patient Meet & Greet
September 25th, 2026 | 5 PM ET
Join NephCure on September 25 at 5 PM ET for a special C3G Awareness Day live conversation featuring Hyo Jin Heinz of CompCure and Lindsey Fuller of C3G Warriors.
Moderated by NephCure’s Kendra Caruth, this candid conversation will explore what it means to live with C3 Glomerulopathy (C3G), from the first signs and the path to diagnosis to navigating treatment, self-advocacy, research, family, and the emotional and physical challenges of rare kidney disease. Hyo Jin and Lindsey will share their personal experiences, what they wish they had known when they were first diagnosed, and where they find hope today.
The conversation will conclude with a live audience Q&A, giving patients, caregivers, and families an opportunity to ask questions and hear directly from people who understand the C3G journey.
Tune in live on NephCure’s Facebook, Instagram, LinkedIn, or YouTube and join us for an evening of honest conversation, education, community, and hope.
Register now
How You Can Get Involved
Help bring C3G into the spotlight. Download our C3G Awareness Day Social Media Toolkit and share facts, graphics, and resources with your community.
Whether you are a patient, caregiver, healthcare professional, researcher, family member, or supporter, your voice can help more people understand C3G.
Tag @NephCure and join the conversation on September 25.
A New Chapter in C3G Treatment
New Treatment Options for C3G
In 2025, new therapies were approved for C3G, providing additional treatment options for eligible patients and marking an important advancement for the C3G community. EMPAVELI® (pegcetacoplan) An FDA-approved treatment for adolescents and adults ages 12 and older with C3G. FABHALTA® (iptacopan) An FDA-approved treatment for adults ages 18 and older with C3G.
Talk with your healthcare provider about your individual condition and treatment options.
Resources for Your C3G Journey
Knowledge can help you feel more prepared for what comes next.
The C3G Handbook provides trusted information to help patients and caregivers better understand C3G, navigate conversations with their healthcare team, and find resources and support throughout their journey. Thank you CompCure and C3G Warriors for their partnership in offering this wonderful resource!
Whether you are newly diagnosed or have been living with C3G for years, the handbook is here to help.
Get Your Free Handbook
Other C3G Resources
Thank You to Our C3G Awareness Day 2026 Sponsors
We are grateful to the organizations supporting C3G Awareness Day and helping NephCure expand education, awareness, and resources for the C3G community.
Help Create a Better Future for the C3G Community
This C3G Awareness Day, help NephCure raise awareness, support patients and families, and advance research toward better treatments and a cure. Together, we can create a future where no one affected by C3G has to navigate this rare disease alone.
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