Matthias Kretzler, M.D.

Computational Medicine and Biology at University of Michigan
Dr. Matthias Kretzler graduated from the University of Heidelberg, Germany. He completed his internal medicine residency and a nephrology fellowship at the University of Munich, Germany. He is a past research fellow in physiology and nephrology at the University of Michigan, and has a special interest in the diagnosis and management of glomerular diseases and diabetic kidney disease.

The overarching goal of Dr.Kretzlers research is to define glomerular disease in mechanistic terms and use this knowledge for targeted therapeutic interventions. To reach this goal the Michigan Kidney Translational Medicine Center (MiKTMC) he leads has developed a translational research pipeline centered on integrated systems biology analysis of renal disease. 25 years of experience in interdisciplinary data integration of large-scale data sets allows to define cross cutting disease mechanism in international multi-disciplinary research networks in the US, Europe, China and sub-Saharan Africa. The MiKTMC teams under Dr. Kretzler’s supervision links carefully monitored environmental exposures, genetic predispositions, transcriptional networks, proteomic profiles, metabolic fingerprints, digital histological data and prospective clinical disease characterization to define cross-cutting disease mechanisms. The molecular mechanism identified have result in more than 450 publications, but most importantly, in new disease predictors, de novo drug development and successful clinical trials of novel therapeutic modalities in kidney disease, see MiKTMC.org.

Selected Publications
Luan F, Trillsch F, Henger A, Eichinger F, Norman S, Appelman H, Kretzler M: A Pilot Study of Gene Expression Based Catagorization of Pancreas Transplant Biopsies. Transplantation, in press.

Sanchez-Nino MD, Sanz AB, Ihalmo P, Lassila M, Holthofer H, Mezzano S, Aros C, Groop PH, Saleem MA, Mathieson PW, Langham R, Kretzler M, Nair V, Lemley K, Nelson RG, Mervaala E, Mattinzoli D, Rastaldi MP, Ruiz-Ortega M, Martin-Ventura JL, Egido J, Ortiz A: The MIF receptor CD74 in diabetic podocyte injury. J Am Soc Nephrol, in press.

Tian Y, Patel JM, Nair V, Martini S, Kretzler M: “Periscope/GQ: A Graph Querying Toolkit.” In the 34th International Conference on Very Large Databases. Auckland , New Zealand , August 24-30, 2008 , demo paper (in press).

Lindenmeyer MT , Rastaldi MP, Ikehata M, Neusser MA, Kretzler M, Cohen CD, Schlondorff D: Endoplasmic Reticulum Stress is Induced by Proteinuria in Human Diabetic Nephropathy and Minimal Change Disease. J Am Soc Nephrol, in press.

Raffetseder U, Rauen T, Djudjaj S, Kretzler M, En-Nia A, Tacke F, Zimmerman HW, Nelson PJ, Frye BC, Floege J, Stefanidis I, Weber C, Mertens PR: Differential regulation of chemokine CCL5 expression in monocytes/macrophages and renal cells by Y-box protein-1. epub PMID, 18800033, 2008

Zhang H, Saha J, Byun J, Schin M, Lorenz M, Kennedy RT, Kretzler M, Feldman EL, Pennathur S, Brosius 3rd FC: Rosiglitazone Reduces Renal and Plasma Markers of Oxidative Injury and Reverses Urinary Metabolite Abnormalities in the Amelioration of Diabetic Nephropathy. Am J Physiol Renal Physiol, epub PMID, 18667486, 2008

Cohen CD, Lindenmeyer MT, Eichinger F, Hahn A, Seifert M, Moll AG, Schmid H, Kiss E, Grone E, Grone HJ, Kretzler M, Werner T, Nelson PJ: Improved elucidation of biological processes linked to diabetic nephropathy by single probe-based microarray data analysis. PLoS ONE, 13, e2937, 2008.

Martini S, Eichinger F, Nair V, Kretzler M: Defining human diabetic nephropathy on the molecular level: Integration of transcriptomic profiles with biological knowledge. Rev Endocr Metab Disord, epub PMID: 18704688, 2008

Wiggin TD, Kretzler M, Pennathur S, Sullivan KA, Brosius FC, Feldman EL: Rosiglitazone Treatment Reduces Diabetic Nephropathy in STZ Treated DBA/2J Mice. Endocrinology, epub, PMID, 18583417, 2008.

Neusser MA, Lindenmeyer MT , Kretzler M, Cohen CD: Genomic analysis in nephrology –towards systems biology and systematic medicine? Nephrol Ther, epub, PMID18586598, 2008.

Shi X, Qu H, Kretzler M, Wu C: The roles of PINCH-2 in regulation of glomerular cell shape change and fibronectin matrix deposition. Am J Physiol Renal Physiol, 295, F253-63, 2008.

Lorz C, Benito-Marin A, Boucherot A, Ucero AC, Rastaldi MP, Henger A, Armelloni S, Santamaria B,Berthier CC, Kretzler M*, Egido J, Ortiz A* (*corresponding authors): Apoptosis gene expression in human diabetic nephropathy: focus on TRAIL. J Am Soc Nephrol, 19, 904-14, 2008.

University of Michigan