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Mira Krendel, Ph.D.
NephCure Young Investigator Awardee
Dr. Krendel is an Assistant Professor of Cell and Developmental Biology at SUNY Upstate Medical University and a 2009 recipient of a NephCure Young Investigator Grant. Studies in her lab focus on the roles of fundamental cell biological processes such as cell motility, cell adhesion and membrane trafficking in the pathogenesis of human diseases, such as cancer, diabetes, and chronic kidney disease. Dr. Krendel earned her Ph.D. from Rutgers University.
Syracuse, New York
SUNY Upstate Medical University
Lay Summary of the Project:
Complex cells such as podocytes have cytoskeletons that maintain cell structure. Dr. Krendel has found that mutations in myosin 1e, a protein in the cytoskeleton of the podocyte, result in severe defects in the glomerulus. Additionally, myosin 1e interacts with synaptopodin, an important regulator of podocytes. Dr. Krendel hypothesizes that this interaction is involved in regulating the podocyte, and she is examining the mechanism that causes myosin 1e loss and resulting podocyte dysfunction and NS. In addition to examining this interaction at the molecular level, Dr. Krendel is testing the role of myosin 1e and synaptopodin interaction in renal functions in a mouse model.Towards personalized molecular medicine of Nephrotic Syndrome: Transcriptional network analysis to predict treatment response of FSGS.
