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Home / Managing RKD / Clinical Trials / I CAN Clinical Study for Patients with IgAN

I CAN Clinical Study for Patients with IgAN

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Brief Description

The purpose of the I CAN Study is to evaluate the safety and effectiveness of ravulizumab compared with placebo to potentially help manage symptoms in adults who have IgAN

Trial Physician / Study Coordinator

Divya Seth

Email Phone
Estimated Enrollment

470

Estimated End Date

07/2027

Trial is for people with

• Be at least 18 years of age • Have a diagnosis of IgAN based on kidney biopsy • Have been treated with stable doses of blood ...

Study Goal

Through the I CAN study, we aim to prioritize research to aid the global IgAN community.

What is involved for the patient?

Screening: Lasts approximately six weeks and includes two visits. The study team will review your medical history and perform tests to ...

About the drug or intervention

The study medication is called ravulizumab (ALXN1210). It is being used in the study for research purposes only. While ravulizumab has ...

Find other locations for this trial:
San Francisco, CA (UCSF Nephrology GN Center)

I'm Interested in this Trial

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Disclaimer

By clicking the submit button, your information and results will be sent to the study coordinator. Submitting the form does not guarantee enrollment but helps determine potential eligibility and connects you with the study team. Please consult your healthcare provider before pursuing participation in any trial.

Frequently Asked Questions

Nephrotic Syndrome is not a disease itself, but rather a group of signs and symptoms that result from damage in the part of the kidney that filters blood (glomeruli).

Common symptoms include:

  • Foamy urine (called proteinuria) caused by protein “spilling” into the urine
  • Severe swelling in parts of the body, most noticeably around the eyes, hands, feet, and abdomen (called edema)
  • Weight gain due to a buildup of extra fluid
  • Fatigue
  • Loss of appetite
  • Low levels of protein in the blood (hypoalbuminemia)
  • Higher than normal fat and cholesterol levels in the blood (hyperlipidemia)

Nephrotic Syndrome can typically be diagnosed with a urine test.

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Nephrotic Syndrome can be “primary” or “secondary” in nature.

Diseases that affect only the kidneys are called primary causes of Nephrotic Syndrome. Doctors often call these diseases “idiopathic,” which means that they arise from an unknown cause. Some of these diseases include:

  • Minimal Change Disease (MCD) – most common in children
  • Focal Segmental Glomerulosclerosis (FSGS)
  • Membranous Nephropathy (MN) – most common in adults
  • IgA Nephropathy (IgAN)

Secondary Nephrotic Syndrome is caused by an underlying, systemic condition like diabetes, lupus, HIV, and others.

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Clinical studies are any studies that involve people. There are two main types: observational and interventional. In an observational trial, researchers track health outcomes over time in groups of participants to look for patterns that help us better understand a disease. In an interventional trial, participants receive specific interventions, which can include new treatments or behavorial changes (e.g., diet changes). To learn more about clinical research, please visit the NephCure website.

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