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Overview and Symptoms:
Minimal Change Disease (MCD) is a disorder affecting the filtering units of the kidney (glomeruli) that can lead to symptoms associated with Nephrotic Syndrome. Some symptoms of NS include:
Proteinuria– Large amounts of protein ‘spilling’ into the urine
Edema – Swelling in parts of the body, most noticeable around the eyes, hands, and feet that become painful
Hypertension – High blood pressure
Hypoproteinemia – Low blood protein
Hypercholesterolemia – High level of cholesterol
Fast Facts
MCD is the most common cause of NS in children associated with 80 to 90% of cases.
It is also seen in adults, but makes up only 10 to 15% of NS cases.
Up to 50% of adult MCD patients that go into
remission will relapse.
Males are twice as likely to have MCD as females.
If MCD does not recur for three years, there is a good chance that it will not return.
Treating Your Disease
Short-Term Goals
The short-term goal of treatment is to stop protein from spilling completely (remission) or lower the amount of protein lost in the urine as much as possible
Long-Term Goals
The long-term goals of treatment include preventing relapses of protein in the urine and preventing the deterioration of kidney function.
There are no currently FDA-approved medication options for MCD. The standard first-line treatment for MCD is Prednisone, a corticosteroid.
How to Live With Your Disease
1
Following a low fat, low sodium diet will help improve your kidneys’ function and your MCD symptoms.
2
Finding a nephrologist that specializes in MCD is very important to your long-term health.
3
Learn about your disease, treatment options, and clinical trials in order to better advocate for yourself.
4
NephCure Kidney International can help you connect with other patients and find support to manage your disease.
