Anna Greka, M.D., Ph.D.

Post-Doctoral Fellow

Anna Greka is an institute member of the Broad Institute of MIT and Harvard, where she directs the institute’s Kidney Disease Initiative. Greka is a physician-scientist leading the translation of scientific discoveries from the laboratory to clinical trials. She is an associate professor at Harvard Medical School (HMS); an associate physician in the Renal Division in the Department of Medicine at Brigham and Women’s Hospital (BWH); and the founding director of Kidney-NExT, a Center for Kidney Disease and Novel Experimental Therapeutics at BWH and HMS.

Boston, Massachusetts

Massachusetts General Hospital

Lay Summary of the Project:

Cells are regulated by signals that direct the movement of substances into and out of the cells through pores or channels. Channels in the podocytes interact, and a mutation in a gene of one ion channel (TRPC6) is linked to podocyte injury and may play a role in FSGS. Dr. Greka is studying the mechanisms that control channels to help identify a possible cause of FSGS. Findings may help identify targets for the development of drug therapies.


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