Children on Prednisone Prednisone is a widely used initial therapy for Nephrotic Syndrome. Prednisone is an immunosuppressant which helps reduce swelling, and, hopefully, helps the kidneys to function properly. As with any treatment, risks and benefits must be weighed. We’ve compiled the following list of common concerns and side effects for anyone with a child taking prednisone. Pediatric concerns for prednisone include: Improper growth and development Behavior or attention problems Unhealthy weight gain Acne Other common side effects include: Weight gain Fluid retention Raised blood pressure Sleeplessness Increased hunger Stretch marks Cataracts Thinning of bones (osteoporosis) Risks of serious infections Ulcers Adrenal insufficiency FACT: It is important prednisone is not stopped abruptly without talking to your doctor. It is very common to taper use of the drug before stopping completely.