Life for Adults while on Prednisone Prednisone is a widely used initial therapy for Nephrotic Syndrome. Prednisone is an immunosuppressant which helps reduce swelling, and, hopefully, helps the kidneys to function properly. Common side effects include: Weight gain Fluid retention Raised blood pressure Sleeplessness Increased hunger Stretch marks Cataracts Thinning of bones (osteoporosis) Risks of serious infections Ulcers Adrenal insufficiency It is important that you do not stop taking prednisone abruptly without talking to your doctor. It is very common to taper use of the drug before stopping completely.