What is Nephrotic Syndrome and How Does it Relate to Proteinuria?
Nephrotic Syndrome (NS) is not a disease itself, but rather a set of signs and symptoms that result from defects in the kidney filters (glomeruli) and can be “primary” or “secondary” in nature.
Patients with NS often experience symptoms of:
- Swelling (edema)
- Shortness of breath
- Allergy-like symptoms
- Less frequent urination
- Weight gain from excess water
- Proteinuria – high protein levels in urine
- Laboratory findings associated with NS
- High cholesterol
- High blood pressure
- Low levels of the protein in blood
- High creatinine levels in blood
Other consequences of losing protein in the urine:
- Loss of anti-clotting proteins increases risk of blood clots
- Loss of vitamin D binding proteins increases risk of bone diseases
- Loss of Immunoglobulin G (IgG) and complement increases risk of infections
Types of Nephrotic Syndrome:
- Minimal Change Disease (MCD)- most common in children• Focal Segmental Glomerulosclerosis (FSGS)
- Membranous Nephropathy (MN)- most common in adults
Other Glomerular Diseases:
- Mesangial Proliferative
- Focal Global Sclerosis
Click here to learn more about Nephrotic Syndrome
Click here to learn more about getting tested for Proteinuria
NephCure Kidney International (NKI) is a patient advocacy organization and is not licensed to practice medicine. The information on this site is intended to be educational and not diagnostic or recommended treatment. Consult with your doctor if you learn anything that might alarm you or if you have any questions.
NephCure thanks Questcor Pharmaceuticals for its support of the Proteinuria Resource Center.