Other Glomerular Diseases Primary glomerular disease means that the condition occurs on its own, without another known systemic disease such as lupus or diabetes. These diseases are also known as idiopathic (having no known cause), and cause Nephrotic Syndrome. There are many similarities in symptoms and treatment options of all forms of Nephrotic Syndrome. However, each type of primary Nephrotic Syndrome listed below has disease specific distinctions. Click below to read more specifically about each. Alport Syndrome C1q Nephropathy IgM Nephropathy Membranoproliferative Glomerulonephritis (MPGN)