{"id":38008,"date":"2026-04-22T16:59:48","date_gmt":"2026-04-22T20:59:48","guid":{"rendered":"https:\/\/nephcure.org\/?p=38008"},"modified":"2026-04-22T17:15:13","modified_gmt":"2026-04-22T21:15:13","slug":"sparsentan-filspari-for-fsgs-faqs","status":"publish","type":"post","link":"https:\/\/nephcure.org\/es\/sparsentan-filspari-for-fsgs-faqs\/","title":{"rendered":"Sparsentan\u00a0(FILSPARI) for FSGS:\u00a0FAQs"},"content":{"rendered":"<div class=\"gb-container gb-container-dd8c1861\">\n\n<figure class=\"gb-block-image gb-block-image-1cfcfb12\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-1cfcfb12\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"l\u00ednea de rumbo\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-92fd2976 gb-headline-text\"><strong>Questions about sparsentan (FILSPARI)<\/strong><\/h2>\n\n\n<div class=\"gb-container gb-container-fca1b152 gb-accordion\">\n<div class=\"gb-container gb-container-0c9ce833 gb-accordion__item gb-accordion__item-open\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-0e40bd57 gb-accordion__toggle gb-block-is-current\" id=\"gb-accordion-toggle-0e40bd57\"><span class=\"gb-button-text\"><strong>What conditions is sparsentan approved to treat?<\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-33545c2e\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-33545c2e\">\n\n<p class=\"wp-block-paragraph\">Sparsentan (FILSPARI) is a prescription medicine approved by the FDA to reduce proteinuria in adults and children 8 years of age and older with focal segmental glomerulosclerosis (FSGS) who do not have nephrotic syndrome.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sparsentan is also approved to slow kidney function decline in adults with primary immunoglobulin A nephropathy (IgAN) who are at risk for disease progression<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-dd690b3f gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-4a81b993 gb-accordion__toggle\" id=\"gb-accordion-toggle-4a81b993\"><span class=\"gb-button-text\"><strong><strong>How does sparsentan work?<\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-22d3c1d4\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-22d3c1d4\">\n\n<p class=\"wp-block-paragraph\">Sparsentan helps lower the amount of protein leaking into the urine (called proteinuria) without suppressing the immune system.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Protein in the urine is a sign that the kidneys are being damaged. By lowering protein levels in the urine, sparsentan helps protect the kidneys and may help slow how quickly the disease gets worse and decline in kidney function.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Sparsentan works to block cells in the body from making two proteins that are believed to contribute to kidney damage: endothelin and angiotensin II. These two proteins play a key role in pathways that are known to create a harmful cycle with urine protein. For example, endothelin is thought to be involved in inflammation that can damage and scar kidney filters. Blocking these two proteins is protective for the kidneys and helps to reduce urine protein.<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-1292ffb4 gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-d0a814ad gb-accordion__toggle\" id=\"gb-accordion-toggle-d0a814ad\"><span class=\"gb-button-text\"><strong><strong><strong>What kind of medication is sparsentan?<\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-1e30ebd3\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-1e30ebd3\">\n\n<p class=\"wp-block-paragraph\">Sparsentan is an oral treatment (taken by mouth). It is a non-immunosuppressive medication. That means it does not suppress your immune system.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">You may also see sparsentan referred to as a \u201cdual endothelin angiotensin II receptor antagonist\u201d or DEARA. This refers to how sparsentan acts in the body: it blocks cells from making endothelin and angiotensin II.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Patients and families should follow the prescribing information and their healthcare provider\u2019s instructions. Your kidney doctor will explain how this medication should be taken and monitored.<\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-ce9dffd7\">\n\n<figure class=\"gb-block-image gb-block-image-b63201b9\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-b63201b9\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"l\u00ednea de rumbo\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-3e1eb1f6 gb-headline-text\"><strong><strong>Understanding Your Condition<\/strong><\/strong><\/h2>\n\n\n<div class=\"gb-container gb-container-5e5efef1 gb-accordion\">\n<div class=\"gb-container gb-container-d30d62a5 gb-accordion__item gb-accordion__item-open\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-2f504e14 gb-accordion__toggle gb-block-is-current\" id=\"gb-accordion-toggle-2f504e14\"><span class=\"gb-button-text\"><strong><strong>What is FSGS?<\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-62e762f5\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-62e762f5\">\n\n<p class=\"wp-block-paragraph\">FSGS is a term that describes damage to the filtering units (called glomeruli) of the kidneys. It is diagnosed through a kidney biopsy, when a characteristic pattern of scarring is seen in the kidneys.&nbsp;<\/p>\n\n\n<div class=\"gb-container gb-container-67f39289\">\n\n<p class=\"wp-block-paragraph\">focal = some<br>segmental = parts of<br>glomerulo = kidney filters<br>sclerosis = are scarred<\/p>\n\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">This scarring is permanent and can get worse over time. The damage from the scarring prevents those parts of the kidneys from working properly. This can cause protein to spill into the urine when it\u2019s not supposed to, leading to even more damage.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">&nbsp;There are four main types of FSGS disease:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Primary FSGS<\/strong> develops on its own, with no known cause. It is believed to be related to an issue in the immune system.<\/li>\n\n\n\n<li><strong>Secondary FSGS<\/strong> occurs due to an identifiable cause, such as a viral infection, medication toxicity, or another medical condition (like obesity or an unrelated autoimmune disease).<\/li>\n\n\n\n<li><strong>GEFS gen\u00e9tica <\/strong>is caused by a change in your genes. It can be inherited from family members or caused by a new gene mutation that was not passed down from either parent.<\/li>\n\n\n\n<li><strong>FSGS of Unknown Cause<\/strong> develops from a cause not yet understood.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">FSGS can affect both children and adults. It can also behave differently from person to person.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Because FSGS can present differently from one person to another, the most important step is to speak with your doctor about what treatment plan is right for you and your current condition.<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-2f5e382a gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-a6880faa gb-accordion__toggle\" id=\"gb-accordion-toggle-a6880faa\"><span class=\"gb-button-text\"><strong><strong><strong>I have been diagnosed with FSGS. How do I find out what type I have?<\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-4a8367c0\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-4a8367c0\">\n\n<p class=\"wp-block-paragraph\">Ask your doctor. You can ask for a copy of your kidney biopsy report and have your doctor explain what it shows.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">You can also ask whether genetic testing may be right for you or your child. For some individuals, genetic testing may help explain the cause of FSGS and help guide care.<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-5241c140 gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-febf21b1 gb-accordion__toggle\" id=\"gb-accordion-toggle-febf21b1\"><span class=\"gb-button-text\"><strong><strong><strong><strong>What is nephrotic syndrome?<\/strong><\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-04a7613e\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-04a7613e\">\n\n<p class=\"wp-block-paragraph\">Nephrotic syndrome is not a disease. It is an umbrella term for a collection of medical signs that occur together. It describes a patient\u2019s current condition and is characterized by the presence of three symptoms happening at the same time:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>proteinuria greater than 3.5 g\/24h<\/li>\n\n\n\n<li>serum albumin less than 3.0 g\/dL<\/li>\n\n\n\n<li>edema (swelling caused by excess fluid buildup)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Your doctor will look at your current physical condition, blood work, and urine samples to determine whether you currently have nephrotic syndrome.<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-31de783d gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-0df5235c gb-accordion__toggle\" id=\"gb-accordion-toggle-0df5235c\"><span class=\"gb-button-text\"><strong><strong><strong><strong><strong>Is nephrotic syndrome the same thing as FSGS?<\/strong><\/strong><\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-455181a3\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-455181a3\">\n\n<p class=\"wp-block-paragraph\">No. While FSGS and nephrotic syndrome may be diagnosed together, they are not the same condition.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">FSGS describes a type of damage seen in the kidney filters on a kidney biopsy.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nephrotic syndrome can be a symptom of FSGS, or a sign of kidney damage, but not all patients with FSGS have nephrotic syndrome.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Many FSGS patients often transition in and out of nephrotic syndrome episodes, depending on how their kidney disease behaves or responds to treatment.<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-f6818300 gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-bb539265 gb-accordion__toggle\" id=\"gb-accordion-toggle-bb539265\"><span class=\"gb-button-text\"><strong><strong><strong><strong><strong><strong>If I currently have FSGS with nephrotic syndrome, what should I do now?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-00408053\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-00408053\">\n\n<p class=\"wp-block-paragraph\">If you currently have nephrotic syndrome, you should continue working closely with your kidney doctor to determine the treatment plan that is right for you.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">FSGS can change over time, and people may move in and out of nephrotic syndrome. If your condition changes and you no longer have nephrotic syndrome, your doctor can adjust your treatment plan to make sure it is right for you.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Regular check-ups are important, so your doctor can see how your condition is changing and help guide your care.<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-d557cbc7 gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-ad5796eb gb-accordion__toggle\" id=\"gb-accordion-toggle-ad5796eb\"><span class=\"gb-button-text\"><strong><strong><strong><strong><strong><strong><strong>Is nephrotic syndrome permanent? If I have FSGS, and I have also been diagnosed with nephrotic syndrome in the past, do I still have it now?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-d7d58d83\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-d7d58d83\">\n\n<p class=\"wp-block-paragraph\">Nephrotic syndrome is not always permanent. It reflects how the disease is behaving at a specific moment in time.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Some patients may have nephrotic syndrome at one point in their journey and not at another. That is why doctors evaluate patients based on their current condition.<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-228acc43 gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-c3c6eccb gb-accordion__toggle\" id=\"gb-accordion-toggle-c3c6eccb\"><span class=\"gb-button-text\"><strong><strong><strong><strong><strong><strong><strong><strong>If I have FSGS but I don\u2019t have nephrotic syndrome, does that mean my FSGS doesn\u2019t need to be treated urgently?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-dc70c071\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-dc70c071\">\n\n<p class=\"wp-block-paragraph\">FSGS without nephrotic syndrome should still be treated as a serious condition.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Some patients who do not have nephrotic syndrome may feel relatively well, but even low levels of protein in the urine can still harm the kidneys over time. That is one reason lowering proteinuria is so important. If you are unsure, talk to your doctor and they can help guide you.<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-00389ebc gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-99523af6 gb-accordion__toggle\" id=\"gb-accordion-toggle-99523af6\"><span class=\"gb-button-text\"><strong><strong><strong><strong><strong><strong><strong><strong><strong>I have genetic, secondary, or FSGS of unknown cause. Could sparsentan be a good fit for me?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-9691e65b\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-9691e65b\">\n\n<p class=\"wp-block-paragraph\">Potentially, yes.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The approved patient population includes all types of FSGS. Your doctor will need to evaluate whether you currently have nephrotic syndrome and what treatment plan is right for you.&nbsp;<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-88764167 gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-c1d1981c gb-accordion__toggle\" id=\"gb-accordion-toggle-c1d1981c\"><span class=\"gb-button-text\"><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong>I was told my condition is \u201cwithout nephrotic syndrome\u201d right now. Should I still care about treatment?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-c0d8ca18\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-c0d8ca18\">\n\n<p class=\"wp-block-paragraph\">Yes. Even if you do not have nephrotic syndrome, it is important to seek treatment. If you have protein in your urine, it means your kidneys are not working as they should. You may not feel sick or have swelling, but damage can still be happening over time.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">That is why lowering protein in the urine is important. It can help protect your kidneys and may help slow down how quickly the disease gets worse. Your doctor can help you decide what treatment is right for you.<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-37ec7765 gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-9885a973 gb-accordion__toggle\" id=\"gb-accordion-toggle-9885a973\"><span class=\"gb-button-text\"><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong><strong>Do I need a biopsy to qualify for sparsentan?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-e9818363\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-e9818363\">\n\n<p class=\"wp-block-paragraph\">Not always. Some patients may need a kidney biopsy to confirm their diagnosis. But in certain cases, a genetic test may be enough. Your doctor will decide which test is right for you based on your condition and medical history.<\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-dc81b78c\">\n\n<figure class=\"gb-block-image gb-block-image-6f07e098\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-6f07e098\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"l\u00ednea de rumbo\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-0024534d gb-headline-text\"><strong><strong><strong>Pediatric and Family FAQs<\/strong><\/strong><\/strong><\/h2>\n\n\n<div class=\"gb-container gb-container-916d658e gb-accordion\">\n<div class=\"gb-container gb-container-0faf2630 gb-accordion__item gb-accordion__item-open\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-a0e431a6 gb-accordion__toggle gb-block-is-current\" id=\"gb-accordion-toggle-a0e431a6\"><span class=\"gb-button-text\"><strong><strong><strong>Why is sparsentan only approved for children 8 years of age and older?<\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-05b73393\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-05b73393\">\n\n<p class=\"wp-block-paragraph\">The FDA approves medicines based on the ages that were included in clinical studies.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">At this time, there is not enough information from studies in children younger than 8 years old. Because of this, sparsentan is only approved for children 8 years of age and older.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Doctors and researchers continue to learn more about how to treat younger children with FSGS<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-8e119cdc gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-d991b521 gb-accordion__toggle\" id=\"gb-accordion-toggle-d991b521\"><span class=\"gb-button-text\"><strong><strong><strong><strong>What if my child cannot swallow pills?<\/strong><\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-9beaf979\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-9beaf979\">\n\n<p class=\"wp-block-paragraph\"><br>For patients who are unable to swallow pills, sparsentan may be crushed and mixed in water right before giving the medication. Your kidney doctor and\/or pharmacist will provide detailed instructions on how to properly crush and mix the pills.\u00a0<\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-e9eff19d\">\n\n<figure class=\"gb-block-image gb-block-image-f0219892\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-f0219892\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"l\u00ednea de rumbo\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-da5d671e gb-headline-text\"><strong><strong><strong><br><strong>Questions <mark class=\"gb-highlight\">A<\/mark>bout Access<\/strong><\/strong><\/strong><\/strong><\/h2>\n\n\n<div class=\"gb-container gb-container-54ab233c gb-accordion\">\n<div class=\"gb-container gb-container-f84f6e90 gb-accordion__item gb-accordion__item-open\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-acfcce4e gb-accordion__toggle gb-block-is-current\" id=\"gb-accordion-toggle-acfcce4e\"><span class=\"gb-button-text\"><strong><strong><strong><strong>When will sparsentan be available?<\/strong><\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-c1d9e5bc\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-c1d9e5bc\">\n\n<p class=\"wp-block-paragraph\">Sparsentan is available for nephrologists to immediately prescribe to individuals with FSGS.<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-5acb8fde gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-c6cda62e gb-accordion__toggle\" id=\"gb-accordion-toggle-c6cda62e\"><span class=\"gb-button-text\"><strong><strong><strong><strong><strong>I heard there is a safety monitoring program for sparsentan. What do I need to know as a patient or caregiver?<\/strong><\/strong><\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-159d9549\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-159d9549\">\n\n<p class=\"wp-block-paragraph\">The FDA requires patients taking sparsentan to follow a Risk Evaluation and Mitigation Strategy (REMS) Program to help you and your doctor monitor liver function. Your doctor will do blood tests to check your liver before starting treatment with sparsentan and every 3 months during treatment.\u00a0<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-d5b73398 gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-b84e5c3b gb-accordion__toggle\" id=\"gb-accordion-toggle-b84e5c3b\"><span class=\"gb-button-text\"><strong><strong><strong><strong><strong><strong>Where can patients and families receive more guidance if prescribed sparsentan?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-f2012637\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-f2012637\">\n\n<p class=\"wp-block-paragraph\">Travere offers Travere TotalCare, a patient support program that offers one-on-one assistance for those prescribed sparsentan, which may include treatment information, financial support, and medication delivery for eligible patients.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Once your doctor submits the prescription, a dedicated Nurse Educator will reach out to you and support you throughout your treatment journey.<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-032d97a3 gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-56882f90 gb-accordion__toggle\" id=\"gb-accordion-toggle-56882f90\"><span class=\"gb-button-text\"><strong><strong><strong><strong><strong><strong><strong>Why was sparsentan only approved for FSGS patients without nephrotic syndrome?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-558ce130\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-558ce130\">\n\n<p class=\"wp-block-paragraph\">Sparsentan was studied in the Phase 3 DUPLEX trial, the largest study in FSGS to date, which included 371 patients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In this study, sparsentan was compared to irbesartan, a commonly used off-label treatment. Additionally, there are no FDA-approved medications for FSGS other than sparsentan. In patients who did not have nephrotic syndrome, sparsentan showed the strongest reduction of protein in the urine. At 108 weeks, protein in the urine was reduced by 48% with sparsentan compared to 27% with irbesartan. FSGS patients without nephrotic syndrome were the group in which results were most clear and supported FDA approval.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These results show that sparsentan can meaningfully lower protein in the urine, which is important for helping protect the kidneys over time.<strong>&nbsp;<\/strong><\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-e7088a42 gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-fb658584 gb-accordion__toggle\" id=\"gb-accordion-toggle-fb658584\"><span class=\"gb-button-text\"><strong><strong><strong><strong><strong><strong><strong><strong>Why is the FDA approval of sparsentan important?<\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/strong><\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M207.029 381.476L12.686 187.132c-9.373-9.373-9.373-24.569 0-33.941l22.667-22.667c9.357-9.357 24.522-9.375 33.901-.04L224 284.505l154.745-154.021c9.379-9.335 24.544-9.317 33.901.04l22.667 22.667c9.373 9.373 9.373 24.569 0 33.941L240.971 381.476c-9.373 9.372-24.569 9.372-33.942 0z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 448 512\" width=\"1em\" height=\"1em\" aria-hidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M240.971 130.524l194.343 194.343c9.373 9.373 9.373 24.569 0 33.941l-22.667 22.667c-9.357 9.357-24.522 9.375-33.901.04L224 227.495 69.255 381.516c-9.379 9.335-24.544 9.317-33.901-.04l-22.667-22.667c-9.373-9.373-9.373-24.569 0-33.941L207.03 130.525c9.372-9.373 24.568-9.373 33.941-.001z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-74f93838\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-74f93838\">\n\n<p class=\"wp-block-paragraph\">This is an important milestone for the FSGS community. For the first time, there is an FDA-approved medicine specifically approved for this condition.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This approval also includes children 8 years of age and older, expanding treatment to a group that is often not included in clinical trials but were in the DUPLEX study. For many patients and families who have waited a long time, this is a potential new treatment option and a big step forward in FSGS care.<\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Questions about sparsentan (FILSPARI) Sparsentan (FILSPARI) is a prescription medicine approved by the FDA to reduce proteinuria in adults and children 8 years of age and older with focal segmental &#8230; <a title=\"Sparsentan\u00a0(FILSPARI) for FSGS:\u00a0FAQs\" class=\"read-more\" href=\"https:\/\/nephcure.org\/es\/sparsentan-filspari-for-fsgs-faqs\/\" aria-label=\"Leer m\u00e1s sobre Sparsentan\u00a0(FILSPARI) for FSGS:\u00a0FAQs\">Leer m\u00e1s<\/a><\/p>","protected":false},"author":12094,"featured_media":30189,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":true,"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[],"disease-category":[253],"resource-type":[246],"treatment-option":[],"hf_cat_post":[],"class_list":["post-38008","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","disease-category-focal-segmental-glomerulosclerosis-fsgs","resource-type-informational-documents"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.5 (Yoast SEO v27.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Sparsentan\u00a0(FILSPARI) for FSGS:\u00a0FAQs - NephCure<\/title>\n<meta name=\"description\" content=\"Questions about sparsentan (FILSPARI) What conditions is sparsentan approved to treat? 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