{"id":30589,"date":"2024-05-28T11:30:44","date_gmt":"2024-05-28T15:30:44","guid":{"rendered":"https:\/\/nephcure.org\/?p=30589"},"modified":"2024-06-11T12:42:54","modified_gmt":"2024-06-11T16:42:54","slug":"nephcures-esfuerzos-continuos-para-educar-y-empoderar-a-las-comunidades-en-la-lucha-contra-la-enfermedad-renal-apol1-3","status":"publish","type":"post","link":"https:\/\/nephcure.org\/es\/a-breakthrough-in-understanding-of-the-cause-of-some-forms-of-rare-kidney-disease-anti-nephrin-autoantibodies\/","title":{"rendered":"Un gran avance en la comprensi\u00f3n de la causa de algunas formas de enfermedad renal rara: los autoanticuerpos antinefrina\u00a0"},"content":{"rendered":"
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A <\/span>estudio multic\u00e9ntrico<\/a>,<\/span> dirigido por el Dr. Tobias Huber y el Dr. Nicola Tomas en Hamburgo, Alemania, ha confirmado que los autoanticuerpos antinefrina (ANAA) se encuentran com\u00fanmente circulando en la sangre de pacientes con enfermedad de cambios m\u00ednimos, s\u00edndrome nefr\u00f3tico idiop\u00e1tico y algunos pacientes con enfermedad focal segmentaria primaria. glomeruloesclerosis (FSGS). <\/span> <\/span><\/p>\n\n\n\n

Este descubrimiento se relaciona con una investigaci\u00f3n anterior de ANAA financiada por NephCure y completada por la Dra. Astrid Weins, que nos permite comprender la causa de algunas formas de enfermedad renal rara (RKD), desarrollar un biomarcador de ANAA o una prueba de laboratorio y comprender mejor qu\u00e9 tratamientos pueden apuntar la causa de estas formas de RKD.<\/span> <\/span><\/p>\n\n\n\n

\u00bfQu\u00e9 es un <\/span>nefrina<\/span>?<\/span><\/strong><\/h6>\n\n\n\n

La nefrina es una prote\u00edna clave en el filtro renal. En los filtros renales, c\u00e9lulas especiales llamadas podocitos se conectan entre s\u00ed mediante procesos similares a dedos. Estas conexiones ayudan a formar una parte importante de la barrera de filtraci\u00f3n renal. La nefrina ayuda a que esta barrera funcione hablando con otras mol\u00e9culas y enviando informaci\u00f3n al podocito. Esto ayuda al podocito a saber c\u00f3mo cambiar su forma y estructura, lo cual es importante para la funci\u00f3n de filtraci\u00f3n de los glom\u00e9rulos. Si la nefrina no funciona correctamente, las prote\u00ednas y otras mol\u00e9culas pueden filtrarse a la orina, provocando una afecci\u00f3n renal como el s\u00edndrome nefr\u00f3tico.\u00a0<\/span><\/span><\/span><\/p>\n\n\n\n

\u00bfQu\u00e9 son los anti-<\/span>nefrina<\/span> autoanticuerpos (ANAA)? \u00bfY qu\u00e9 efecto tienen?<\/span><\/span> <\/span><\/strong><\/h6>\n\n\n\n

ANAA<\/span> son anticuerpos que atacan <\/span>nefrina<\/span> prote\u00ednas en los filtros renales. En este estudio, los investigadores encontraron estos anticuerpos en aproximadamente dos tercios de los adultos con enfermedad de cambios m\u00ednimos y s\u00edndrome nefr\u00f3tico activo antes de comenzar el tratamiento. En ni\u00f1os con s\u00edndrome nefr\u00f3tico idiop\u00e1tico, encontraron estos anticuerpos en el 90% de los casos antes del tratamiento con esteroides. Un n\u00famero menor de pacientes con GEFS primaria tambi\u00e9n ten\u00edan estos anticuerpos. <\/span><\/span> <\/span><\/p>\n\n\n\n

Por el contrario, cuando los pacientes estaban en remisi\u00f3n o no ten\u00edan p\u00e9rdida de prote\u00ednas, estos anticuerpos estaban notablemente reducidos o ausentes, lo que indica <\/span>ANAA <\/span>potencialmente juegan un papel importante en la actividad y progresi\u00f3n de la enfermedad.<\/span><\/span> <\/span><\/p>\n\n\n\n

\u201cEl descubrimiento de anti-<\/span>nefrina<\/span> autoanticuerpos cambia completamente nuestra comprensi\u00f3n del s\u00edndrome nefr\u00f3tico idiop\u00e1tico, la enfermedad de cambios m\u00ednimos y la GEFS primaria, que ahora se clasificar\u00e1 como anti-<\/span>nefrina<\/span> podocitopat\u00edas asociadas\u201d, <\/span>afirm\u00f3 el Dr. Tobias Huber.<\/span><\/span> <\/span><\/p>\n\n\n\n

\u201cEl efecto inmediato de la identificaci\u00f3n de anticuerpos antinefrina como enfermedad espec\u00edfica<\/span> <\/span>"Los marcadores que se correlacionan fuertemente con la actividad de la enfermedad es que por primera vez tenemos a mano un biomarcador sangu\u00edneo, lo que permite realizar un diagn\u00f3stico espec\u00edfico y basado en patobiolog\u00eda".<\/span> <\/span><\/p>\n\n\n\n

\u00bfPor qu\u00e9 es tan importante este descubrimiento?<\/span><\/span> <\/span><\/strong><\/h6>\n\n\n
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Este hallazgo puede cambiar nuestra comprensi\u00f3n del s\u00edndrome nefr\u00f3tico idiop\u00e1tico, la enfermedad de cambios m\u00ednimos y la GEFS primaria. Ahora se considera que estas enfermedades est\u00e1n relacionadas con la antinefrina, lo que ayuda a los pacientes a comprender qu\u00e9 puede estar causando su enfermedad, lo que hace que el t\u00e9rmino "idiop\u00e1tico" (que significa causa desconocida) sea menos preciso.<\/span>\u00a0<\/span>
<\/span><\/p>\n\n\n\n

A trav\u00e9s de estos descubrimientos y estudios futuros, se anticipa que el tratamiento de la enfermedad renal asociada con antinefrina afectar\u00e1 a los pacientes de las siguientes maneras:<\/span>\u00a0<\/span><\/p>\n\n\n\n

1. Diagn\u00f3stico mejorado<\/span><\/b> <\/span><\/p>\n\n\n\n

La presencia de ANAA puede servir como biomarcador o an\u00e1lisis de sangre de diagn\u00f3stico que probablemente proporcionar\u00e1 un diagn\u00f3stico m\u00e1s preciso. Los pacientes que den positivo en las pruebas de ANAA conocer\u00e1n la posible causa de su enfermedad renal y eliminar\u00e1n la naturaleza "idiop\u00e1tica" o desconocida de su diagn\u00f3stico.<\/span> <\/span><\/p>\n\n\n\n

2. Seguimiento de la actividad y el tratamiento de la enfermedad<\/span><\/b><\/p>\n\n\n\n

Los niveles de ANAA pueden correlacionarse con las actividades de la enfermedad, como el inicio, la reca\u00edda, la remisi\u00f3n y la progresi\u00f3n de la enfermedad. La capacidad de eventualmente monitorear los ANAA en la sangre puede permitir mediciones en tiempo real de c\u00f3mo responden los pacientes al tratamiento y estrategias de tratamiento personalizadas basadas en los niveles de anticuerpos.<\/span> <\/span><\/p>\n\n\n\n

3. Enfoques de tratamiento personalizados<\/span><\/b> <\/span><\/p>\n\n\n\n

Los protocolos de tratamiento actuales a menudo implican un enfoque de prueba y error con esteroides y terapias inmunosupresoras no espec\u00edficas, lo que deja a los pacientes sin un est\u00e1ndar de atenci\u00f3n universalmente aceptado. Identificar a los pacientes que dan positivo en las pruebas de anticuerpos antinefrina pronto permitir\u00e1 protocolos de tratamiento m\u00e1s personalizados dirigidos a c\u00e9lulas espec\u00edficas, algunas de las cuales ya est\u00e1n en el mercado. <\/span> <\/span><\/p>\n\n\n\n

Para los pacientes con enfermedad renal en etapa terminal que est\u00e1n considerando un trasplante de ri\u00f1\u00f3n, medir la cantidad de ANAA podr\u00eda convertirse en una parte esencial del trabajo y el tratamiento previos al trasplante para reducir potencialmente el riesgo de recurrencia de la enfermedad posterior al trasplante. <\/span> <\/span><\/p>\n\n\n\n

4. Nuevos medicamentos dirigidos<\/span><\/b> <\/span><\/p>\n\n\n\n

Junto con los medicamentos que ya est\u00e1n en el mercado, una comprensi\u00f3n m\u00e1s profunda de qu\u00e9 factores est\u00e1n causando da\u00f1o a los ri\u00f1ones conducir\u00e1 a nuevas terapias dirigidas a anticuerpos, que abordar\u00e1n los problemas subyacentes. Es probable que estos medicamentos de precisi\u00f3n tambi\u00e9n reduzcan la cantidad de efectos secundarios negativos y mejoren los resultados en comparaci\u00f3n con el uso de medicamentos inmunosupresores.<\/span> <\/span><\/p>\n\n\n\n

5. Comprensi\u00f3n m\u00e1s profunda y nuevas investigaciones<\/span><\/b>\u00a0<\/span><\/p>\n\n\n\n

Hay mucho que aprender sobre c\u00f3mo los ANAA afectan los ri\u00f1ones. Se necesitan m\u00e1s estudios para determinar si se pueden utilizar para predecir la respuesta de un paciente a la terapia, el riesgo de reca\u00edda y el curso de la enfermedad. Este estudio de investigaci\u00f3n es s\u00f3lo el comienzo. Conducir\u00e1 a m\u00e1s investigaciones, a una comprensi\u00f3n m\u00e1s profunda de la enfermedad renal mediada por antinefrina y tambi\u00e9n puede ayudar a identificar otros biomarcadores similares para diferentes formas de RKD.<\/span><\/p>\n\n\n

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A trav\u00e9s de la colaboraci\u00f3n continua entre consorcios de investigaci\u00f3n e instituciones acad\u00e9micas de todo el mundo, organizaciones de m\u00e9dicos y pacientes y personas que viven con RKD, <\/span><\/span>se estima que un disponible comercialmente <\/span>anana <\/span>Se implementar\u00e1 un biomarcador para informar el diagn\u00f3stico y el curso de la enfermedad dentro de 3 a\u00f1os.<\/span> <\/span>(i<\/span>Actualmente est\u00e1 disponible s\u00f3lo en un n\u00famero limitado de laboratorios de investigaci\u00f3n acad\u00e9mica).<\/span><\/span>\u00a0<\/span><\/p>\n\n\n\n

\u201cEl descubrimiento de los anticuerpos antinefrina como una de las principales causas del s\u00edndrome nefr\u00f3tico fue el resultado de tener el entrenamiento y la experiencia para reconocer algo que otros no sab\u00edan, aceptar el desaf\u00edo de caminar por un camino invicto y, por \u00faltimo, pero no menos importante, armar una equipo de creyentes que podr\u00eda ejecutar y realizar un seguimiento con rigor cient\u00edfico\u201d, dijo la Dra. Astrid Weins, investigadora financiada por NephCure.<\/span> <\/span><\/p>\n\n\n\n

Las contribuciones de NephCure a la investigaci\u00f3n para encontrar curas y la defensa de los pacientes siguen siendo la principal prioridad de la organizaci\u00f3n. Este estudio marca un paso crucial hacia revolucionar el panorama del diagn\u00f3stico y tratamiento para algunos pacientes con RKD, permitiendo un manejo y resultados m\u00e1s claros y efectivos. <\/span> <\/span><\/p>\n\n\n\n

\u201cNephCure jug\u00f3 un papel enorme en todo esto. Claramente, este avance cient\u00edfico no habr\u00eda ocurrido sin esa primera reuni\u00f3n de pacientes de NephCure a la que asist\u00ed hace 20 a\u00f1os, toda la investigaci\u00f3n que patrocinaron a lo largo de los a\u00f1os, el intercambio cient\u00edfico que facilitaron y los recursos que ayudaron a crear. Le debo a NephCure una enorme gratitud por todo esto; Pero m\u00e1s<\/span>M\u00e1s importante a\u00fan, por recordarme incansablemente de qu\u00e9 se trata: nuestros pacientes\u201d, a\u00f1adi\u00f3 el Dr. Weins.<\/span><\/p>\n\n\n

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\"\"<\/figure>\n<\/div>\n\n\n
\u00bfC\u00f3mo puedo participar y mantenerme actualizado?\u00a0<\/b>\u00a0<\/h6>\n\n\n\n

Los pacientes pueden desempe\u00f1ar un papel activo al participar en ensayos cl\u00ednicos y otros estudios y registros longitudinales. Ayudar a difundir el mensaje y recopilar datos es<\/span><\/p>\n\n\n\n

fundamental para encontrar nuevas opciones de tratamiento potenciales. <\/span>haga clic aqu\u00ed<\/span><\/a> para obtener m\u00e1s informaci\u00f3n sobre los ensayos cl\u00ednicos actuales de RKD que se est\u00e1n llevando a cabo y ver si es elegible. <\/span>\u00a0<\/span><\/p>\n\n\n\n

Si tiene preguntas espec\u00edficas sobre el descubrimiento de ANAA, comun\u00edquese con NephCure en <\/span>info@nephcure.org<\/span><\/a> o env\u00ede un formulario en nuestro <\/span>P\u00e1gina de servicios de navegaci\u00f3n para pacientes<\/span><\/a>. NephCure continuar\u00e1 publicando actualizaciones sobre esta investigaci\u00f3n. <\/span> <\/span><\/p>","protected":false},"excerpt":{"rendered":"

Un estudio multic\u00e9ntrico, dirigido por el Dr. Tobias Huber y el Dr. Nicola Tomas en Hamburgo, Alemania, ha confirmado que los autoanticuerpos anti-nefrina (ANAA) se encuentran com\u00fanmente circulando en la sangre de los pacientes\u2026 Leer m\u00e1s<\/a><\/p>","protected":false},"author":12083,"featured_media":30592,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[354,299],"tags":[541,542,473,543],"disease-category":[],"resource-type":[260],"treatment-option":[],"hf_cat_post":[544],"class_list":["post-30589","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recent-news","category-research-news","tag-anti-nephrin","tag-anti-nephrin-autoantibodies","tag-kidney-research","tag-studies","resource-type-news"],"acf":[],"yoast_head":"\nA Breakthrough in Understanding of the Cause of Some Forms of Rare 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