{"id":35956,"date":"2025-07-10T18:00:19","date_gmt":"2025-07-10T22:00:19","guid":{"rendered":"https:\/\/nephcure.org\/?page_id=35956"},"modified":"2026-09-17T16:34:03","modified_gmt":"2026-09-17T20:34:03","slug":"vanrafia-atrasentan","status":"publish","type":"page","link":"https:\/\/nephcure.org\/es\/managing-rkd\/treatment-options\/vanrafia-atrasentan\/","title":{"rendered":"VANRAFIA (Atrasentan)"},"content":{"rendered":"
\n
Home<\/a><\/span> \/ Managing RKD<\/a><\/span> \/ Treatment Options<\/a><\/span> \/ VANRAFIA (Atrasentan)<\/span><\/span><\/div>\n\n
\n\n

VANRAFIA (Atrasentan)<\/h1>\n\n\n\n

VANRAFIA, generic name Atrasentan, is a prescription medication that is FDA-approved to treat\u00a0IgA Nephropathy<\/a>. This medication is taken alongside your current medications to help slow the progression of your rare kidney disease. It does not suppress the immune system and is not a steroid.<\/p>\n\n\n\n

Medically reviewed by Dr. Anjay Rastogi, MD PhD and Dr. Gaia Coppock, MD<\/em><\/p>\n\n<\/div>\n<\/section>\n\n

\n\n
\"\"<\/figure>\n\n\n\n

How does VANRAFIA Work?<\/strong><\/h2>\n\n\n\n

VANRAFIA works by blocking receptors in the kidney called endothelin-A receptors. These receptors normally help control blood flow in the kidney. In people with IgA nephropathy, the endothelin receptors can become overactive and cause kidney damage. Doctors often monitor this damage by measuring how much protein is spilling into urine (proteinuria). In studies, researchers found that VANRAFIA lowered proteinuria by about 40% for people with IgA nephropathy.<\/p>\n\n\n

<\/div>\n\n\n
\"\"<\/figure>\n\n\n\n

How is VANRAFIA Administered?<\/strong><\/h2>\n\n\n\n

VANRAFIA (Atrasentan) is a pill that is taken once a day with or without food. It should be swallowed and not crushed.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Is VANRA<\/strong>FIA Right for Me?<\/strong><\/h2>\n\n\n\n

You and your doctor can decide together whether this medication is right for you. In people with IgA nephropathy who have more than 500 mg of protein in their urine, this medication can help to further reduce or lower proteinuria.  Lower proteinuria is associated with preserving kidney function over time.<\/p>\n\n\n\n

*Note: The decision to prescribe a medication is the responsibility of your physician\/primary care provider based on his\/her evaluation of your condition. The above is meant for informational purposes only. Discuss this information and all information about drugs\/medications with your physician before starting or stopping any medication.\u201d<\/em><\/p>\n\n<\/div>\n\n

\n\n
\"\"<\/figure>\n\n\n\n

Frequently Asked Questions<\/h2>\n\n\n
\n
\n\n