{"id":35757,"date":"2025-05-22T13:31:25","date_gmt":"2025-05-22T17:31:25","guid":{"rendered":"https:\/\/nephcure.org\/?page_id=35757"},"modified":"2025-09-30T15:17:00","modified_gmt":"2025-09-30T19:17:00","slug":"the-parasol-project","status":"publish","type":"page","link":"https:\/\/nephcure.org\/es\/the-parasol-project\/","title":{"rendered":"El Proyecto PARASOL"},"content":{"rendered":"<section class=\"gb-container gb-container-ba2e2dcb\">\n<div class=\"yoast-breadcrumbs breadcrumb\"><span><span><a href=\"https:\/\/nephcure.org\/\">Home<\/a><\/span> \/ <span class=\"breadcrumb_last\" aria-current=\"page\">The PARASOL Project<\/span><\/span><\/div>\n\n<div class=\"gb-container gb-container-80071c84 hero-copy\">\n\n<h1 class=\"gb-headline gb-headline-6cf43bd0 gb-headline-text hero-content\"><strong>The PARASOL Project: Pioneering the Use of Proteinuria as an Endpoint for FSGS<\/strong>&nbsp;<\/h1>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">A groundbreaking initiative that accelerated research, collaboration, and innovation in rare kidney diseases.&nbsp;<\/p>\n\n\n\n<a class=\"gb-button gb-button-52ab81c1 gb-button-text gb-button-primary button\" href=\"https:\/\/www.is-gd.org\/parasol\" target=\"_blank\" rel=\"noopener noreferrer\">stay informed<\/a>\n\n\n<div class=\"gb-container gb-container-f66b43c9\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-6725fec2\">\n<div class=\"gb-grid-column gb-grid-column-b0e37461\"><div class=\"gb-container gb-container-b0e37461\">\n\n<figure class=\"gb-block-image gb-block-image-8f07cf6d\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-8f07cf6d\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"Headline decoration line\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-what-is-parasol-nbsp\" style=\"font-size:25px\"><strong><strong>What is PARASOL?<\/strong>&nbsp;<\/strong><\/h4>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">The <strong>PARASOL (Proteinuria and GFR as Clinical Trial Endpoints in <\/strong><a href=\"https:\/\/nephcure.org\/intro-to-rkd\/types-of-rkd\/focal-segmental-glomerulosclerosis-fsgs\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Focal Segmental Glomerulosclerosis [FSGS]<\/strong><\/a><strong>) Project<\/strong> is a pioneering initiative co-sponsored by NephCure, the International Society of Glomerular Disease, the U.S. Food and Drug Administration, the Kidney Health Initiative, and the National Kidney Foundation. The primary goal of the project, that started in December 2023, was to validate the use of proteinuria and eGFR-based surrogate endpoints for the accelerated and traditional approval of new treatments for FSGS, facilitating the development of urgently needed therapies.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The collaborative project brought together leading researchers, nephrologists, biostatisticians, industry leaders, patient advocates, and regulatory authorities to drive scientific progress for rare kidney disease treatments.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">At its core, PARASOL aimed to:&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Support critical studies through a targeted grant program&nbsp;<\/li>\n\n\n\n<li>Facilitate collaboration via scientific workshops and industry partnerships&nbsp;<\/li>\n\n\n\n<li>Drive innovation toward better diagnostics and treatment options<\/li>\n<\/ul>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-9849f448\"><\/div>\n\n<div class=\"gb-container gb-container-3fac850f\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-db954a44\">\n<div class=\"gb-grid-column gb-grid-column-eadc57e4\"><div class=\"gb-container gb-container-eadc57e4\">\n\n<figure class=\"gb-block-image gb-block-image-13938e28\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-13938e28\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"Headline decoration line\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-why-it-mattered-nbsp\" style=\"font-size:25px\"><strong><strong>Why it Mattered<\/strong>?&nbsp;<\/strong><\/h4>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Using proteinuria as a reliable clinical trial endpoint was key to improving treatments and outcomes for FSGS patients. PARASOL accelerated this effort by uniting the scientific, clinical, and regulatory communities around a shared goal \u2014 with a notably aggressive project timeline that moved the field forward faster than traditional research efforts.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cPARASOL is an incredible demonstration by the international nephrology community that through generosity and multidisciplinary collaboration, we can answer fundamental, practical scientific questions needed to inform clinical trial design in rare disease,\u201d said Dr. Laura Mariani, PARASOL Co-Chair and Associate Professor of Medicine (Nephrology) at the University of Michigan.&nbsp;<\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/section>\n\n<div class=\"gb-container gb-container-0c99a82e\">\n\n<figure class=\"gb-block-image gb-block-image-66954f8c\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-66954f8c\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-49d312e7 gb-headline-text\"><strong>Building Global Consensus Through Scientific Workshops&nbsp;<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A cornerstone of the PARASOL Project was its <a href=\"https:\/\/www.is-gd.org\/parasol-sci-workshop-oct24\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>three international scientific workshops<\/strong><\/a>, designed to unite top nephrology experts, regulatory authorities, patient advocates, and industry partners around the world using proteinuria and eGFR as clinical trial endpoints for FSGS.<\/p>\n\n<\/div>\n\n<div class=\"gb-container gb-container-703346ae\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-542c04e0\">\n<div class=\"gb-grid-column gb-grid-column-cc8ee133\"><div class=\"gb-container gb-container-cc8ee133\">\n\n<figure class=\"gb-block-image gb-block-image-b4ae0301\"><img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"1707\" class=\"gb-image gb-image-b4ae0301\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6445-scaled.jpg\" alt=\"\" title=\"IMG_6445\" srcset=\"https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6445-scaled.jpg 2560w, https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6445-300x200.jpg 300w, https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6445-1024x683.jpg 1024w, https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6445-768x512.jpg 768w, https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6445-1536x1024.jpg 1536w, https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6445-2048x1365.jpg 2048w, https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6445-18x12.jpg 18w, https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6445-600x400.jpg 600w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><\/figure>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-bccfd069\"><div class=\"gb-container gb-container-bccfd069\">\n\n<figure class=\"gb-block-image gb-block-image-178a792a\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-178a792a\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-aaa60fb9 gb-headline-text\"><strong><strong>Washington, D.C., Inaugural Meeting<\/strong>&nbsp;<\/strong><\/h2>\n\n\n<div class=\"gb-container gb-container-73927d0f\"><\/div>\n\n\n<p class=\"wp-block-paragraph\">The first PARASOL meeting took place in Washington, D.C., on December 9-10, 2023. Researchers, clinicians, regulators, and patients gathered to discuss developing biostatistical models to better design clinical trials and predict outcomes like kidney failure. They focused on accounting for variability in proteinuria and eGFR and emphasized the need to merge global datasets. The meeting set the foundation for creating practical tools that would improve FSGS clinical trials and drug development strategies. <a href=\"https:\/\/nephcure.org\/globalcollaborationatparasolproject-fsgs-clinicaltrials-newtreatmentoptions\/\" target=\"_blank\" rel=\"noreferrer noopener\">Click here for full details.<\/a>&nbsp;&nbsp;<\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-66a1f6a3 hero-copy\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-4cb074f0\">\n<div class=\"gb-grid-column gb-grid-column-8e2391f8\"><div class=\"gb-container gb-container-8e2391f8\">\n\n<figure class=\"gb-block-image gb-block-image-f7f82062\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-f7f82062\" src=\"https:\/\/nephcuredev.wpengine.com\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-3d4808ec gb-headline-text\"><strong>Reykjavik, Iceland Workshop<\/strong>&nbsp;<\/h2>\n\n\n\n<p class=\"has-text-align-left wp-block-paragraph\">The first major scientific convening of the PARASOL Project took place on June 8\u20139, 2024, in Reykjavik, Iceland, and marked a significant milestone in the fight against FSGS.&nbsp;<br>This second overall meeting of PARASOL stakeholders (following the project launch in December 2023) focused on advancing efforts to identify alternative, data-driven endpoints for FSGS clinical trials \u2014 beyond the complete remission markers traditionally recognized by the FDA.&nbsp;<\/p>\n\n\n\n<p class=\"has-text-align-left wp-block-paragraph\">Patient-level data assembled from more than 20 international cohorts and registries representing over 3,000 patients were central to the meeting. &nbsp;<\/p>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-152f8901\"><div class=\"gb-container gb-container-152f8901 video-wrapper\">\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"PARASOL Project\" width=\"1200\" height=\"675\" src=\"https:\/\/www.youtube.com\/embed\/6rf6EljREqw?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n<\/div><\/div>\n<\/div>\n\n\n<p class=\"has-text-align-left wp-block-paragraph\">Early analyses from datasets such as NEPTUNE, CureGN, the Kidney Research Network, and the UNC Glomerular Disease Collaborative Research Network (GDCRN) were presented.<\/p>\n\n\n\n<p class=\"has-text-align-left wp-block-paragraph\">Breakout sessions and robust discussions examined whether <strong>l<\/strong>esser degrees of proteinuria reduction could support accelerated or traditional treatment approvals. The gathering emphasized the urgent need to develop appropriate, feasible indicators of disease progression to help bring new therapies to patients faster.&nbsp;<\/p>\n\n\n\n<p class=\"has-text-align-left wp-block-paragraph\">\u201cWe are truly inspired by the community\u2019s response to PARASOL, especially the eagerness of nephrologists and their teams to share their data,\u201d said Dr. Matthias Kretzler, PARASOL Project Co-Chair.&nbsp;<\/p>\n\n\n\n<p class=\"has-text-align-left wp-block-paragraph\">\u201cIt was incredibly gratifying to have such a diverse group of stakeholders all in one room, fostering robust and vital discussions,\u201d added Josh Tarnoff, CEO of NephCure.&nbsp;<\/p>\n\n\n\n<p class=\"has-text-align-left wp-block-paragraph\">The Reykjavik meeting paved the way for focused next steps, additional data integration, and more comprehensive discussions at the following workshop.&nbsp;<\/p>\n\n<\/div>\n\n<div class=\"gb-container gb-container-b45e9505\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-d4ac8e2d\">\n<div class=\"gb-grid-column gb-grid-column-252bc541\"><div class=\"gb-container gb-container-252bc541\">\n\n<figure class=\"gb-block-image gb-block-image-4ac64150\"><img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"1707\" class=\"gb-image gb-image-4ac64150\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6456-scaled.jpg\" alt=\"\" title=\"IMG_6456\" srcset=\"https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6456-scaled.jpg 2560w, https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6456-300x200.jpg 300w, https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6456-1024x683.jpg 1024w, https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6456-768x512.jpg 768w, https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6456-1536x1024.jpg 1536w, https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6456-2048x1365.jpg 2048w, https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6456-18x12.jpg 18w, https:\/\/nephcure.org\/wp-content\/uploads\/2025\/05\/IMG_6456-600x400.jpg 600w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><\/figure>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-93bfef93\"><div class=\"gb-container gb-container-93bfef93\">\n\n<figure class=\"gb-block-image gb-block-image-d95bd0b8\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-d95bd0b8\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-8b25774b gb-headline-text\"><strong><strong>Bethesda, Maryland Workshop<\/strong>&nbsp;<\/strong><\/h2>\n\n\n<div class=\"gb-container gb-container-aab7cdfb\"><\/div>\n\n\n<p class=\"wp-block-paragraph\">On <strong>October 7\u20138, 2024<\/strong>, <a href=\"https:\/\/nephcure.org\/parasol-project-advances-understanding-of-proteinuria-in-fsgs\/\" target=\"_blank\" rel=\"noreferrer noopener\">PARASOL hosted a scientific workshop in Bethesda, Maryland,<\/a> bringing the project&#8217;s work to a critical point.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">At this workshop, detailed biostatistical analyses of 1,626 FSGS patients were presented, drawing from the global datasets assembled earlier in the year.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dr. Abigail Smith reported that reductions in proteinuria over 24 months were strongly associated with a reduced risk of kidney failure, findings that were consistent across different patient subgroups and validated in a large independent European cohort. The discussion highlighted the biological plausibility of proteinuria as a surrogate marker, its broad utility in clinical trial design, and the potential to accelerate drug development for FSGS.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201cThrough generosity and multidisciplinary collaboration, we can answer fundamental scientific questions needed to inform rare disease trial design,\u201d said Dr. Laura Mariani, PARASOL Co-Chair.&nbsp;&nbsp;<\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-03551d3b\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-e1643840\">\n<div class=\"gb-grid-column gb-grid-column-e94f6792\"><div class=\"gb-container gb-container-e94f6792\">\n\n<figure class=\"gb-block-image gb-block-image-1580b666\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-1580b666\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"Headline decoration line\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-parasol-conclusions-nbsp\" style=\"font-size:25px\"><strong><strong><strong>PARASOL Conclusions<\/strong>&nbsp;<\/strong><\/strong><\/h4>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">The Maryland meeting successfully finalized key findings that were shared at the American Society of Nephrology Kidney Week 2024 and prepared for publication in a peer-reviewed journal. &nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This progress has already started to impact the field. Travere Therapeutics announced the FDA has accepted their supplemental New Drug Application (sNDA) to expand the use of <a href=\"https:\/\/nephcure.org\/managing-rkd\/treatment-options\/filspari-sparsentan\/\" target=\"_blank\" rel=\"noreferrer noopener\">FILSPARI<\/a> to treat people with FSGS. The FDA plans to review the application and issue a decision by January 13, 2026. If approved, FILSPARI will become the first FDA-approved treatment specifically for FSGS. This milestone further highlights the importance of the PARASOL Project\u2019s contributions toward advancing regulatory pathways and treatment options for patients with rare kidney diseases. <a href=\"https:\/\/www.nasdaq.com\/press-release\/travere-therapeutics-announces-fda-acceptance-snda-filsparir-sparsentan-fsgs-2025-05\" target=\"_blank\" rel=\"noreferrer noopener\">Click here to learn more.<\/a>&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">On April 28<sup>th<\/sup>, 2025, in Melbourne Australia, Dimerix Limited \u2013 a biopharmaceutical company with a Phase 3 clinical trial asset, DMX-200, in a rare kidney disease, was able to announce a positive advancement due to the progress created by the PARASOL Project. Dimerix met with the US FDA where it was confirmed that proteinuria-based endpoints could be the basis for full marketing approval of DMX-200 in the US. <a href=\"https:\/\/announcements.asx.com.au\/asxpdf\/20250428\/pdf\/06j2kvl538gwxv.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Click here to learn more.<\/a>&nbsp;&nbsp;<\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<section class=\"gb-container gb-container-849b86a7\">\n<div class=\"gb-container gb-container-639129a5\">\n\n<figure class=\"gb-block-image gb-block-image-e5defb8d\"><img loading=\"lazy\" decoding=\"async\" width=\"1920\" height=\"120\" class=\"gb-image gb-image-e5defb8d\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/top-curve.svg\" alt=\"\" title=\"top-curve\"\/><\/figure>\n\n<\/div>\n\n<div class=\"gb-container gb-container-84b68dd5\">\n<div class=\"gb-container gb-container-682d97c1 difference-wrapper\">\n<div class=\"gb-container gb-container-c1dff965\">\n\n<figure class=\"gb-block-image gb-block-image-df332054\"><img loading=\"lazy\" decoding=\"async\" width=\"356\" height=\"447\" class=\"gb-image gb-image-df332054 animated rubberBand\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/kidney-mark.svg\" alt=\"\" title=\"kidney-mark\"\/><\/figure>\n\n<\/div>\n\n<div class=\"gb-container gb-container-826754f7\">\n\n<h2 class=\"gb-headline gb-headline-a7e64ccd gb-headline-text difference-title\"><strong>A New Era of Collaboration<\/strong>&nbsp;<\/h2>\n\n\n\n<p class=\"gb-headline gb-headline-89b36a81 gb-headline-text difference-copy\">Together, these three workshops exemplified the power of international collaboration in rare disease research.&nbsp;They established the scientific consensus needed to support the regulatory acceptance of proteinuria and eGFR as endpoints \u2014 opening the door to faster development and approval of treatments for FSGS.&nbsp;Moving forward, the &#8220;PARASOL formula&#8221; of rapid, collaborative, multi-stakeholder engagement will serve as a model to accelerate research and treatment development for other rare kidney diseases in urgent need of new therapies.&nbsp;<a href=\"https:\/\/nephcure.org\/get-involved\/ways-to-give\/\"><\/a><\/p>\n\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-a59b33c7\">\n\n<figure class=\"gb-block-image gb-block-image-d05c8035\"><img loading=\"lazy\" decoding=\"async\" width=\"1920\" height=\"120\" class=\"gb-image gb-image-d05c8035\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/bottom-curve.svg\" alt=\"\" title=\"bottom-curve\"\/><\/figure>\n\n<\/div>\n<\/section>\n\n<div class=\"gb-container gb-container-8fb1dffe\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-f239b0a1\">\n<div class=\"gb-grid-column gb-grid-column-f9732204\"><div class=\"gb-container gb-container-f9732204\">\n<div class=\"gb-container gb-container-c8b00f84 gb-container-default\">\n\n<figure class=\"gb-block-image gb-block-image-2110858c\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-2110858c\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-d71e3099 gb-headline-text\"><strong><strong><strong>The PARASOL Grant Program: Supporting Breakthrough Research<\/strong>&nbsp;<\/strong><\/strong><\/h2>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\">The PARASOL Grant Program was a key component of the project, providing critical funding to researchers studying proteinuria in FSGS. The grants supported work on:&nbsp;<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"gb-grid-wrapper gb-grid-wrapper-e7fa9c2f\">\n<div class=\"gb-grid-column gb-grid-column-cc0c325c\"><div class=\"gb-container gb-container-cc0c325c\">\n\n<h2 class=\"gb-headline gb-headline-08e3f37b\"><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" viewBox=\"0 0 13 13\" height=\"13\" width=\"13\"> <circle fill=\"#922694\" r=\"6.5\" cy=\"6.5\" cx=\"6.5\"><\/circle> <\/svg><\/span><\/h2>\n\n\n\n<p class=\"gb-headline gb-headline-bde577f0 gb-headline-text\">Mechanisms of proteinuria in FSGS&nbsp;<\/p>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-6cf01900\"><div class=\"gb-container gb-container-6cf01900\">\n\n<h2 class=\"gb-headline gb-headline-8a4263fe\"><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" viewBox=\"0 0 13 13\" height=\"13\" width=\"13\"> <circle fill=\"#922694\" r=\"6.5\" cy=\"6.5\" cx=\"6.5\"><\/circle> <\/svg><\/span><\/h2>\n\n\n\n<p class=\"gb-headline gb-headline-2b421412 gb-headline-text\">Therapeutic targets and potential treatments&nbsp;<\/p>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-8af86d83\"><div class=\"gb-container gb-container-8af86d83\">\n\n<h2 class=\"gb-headline gb-headline-7e0786da\"><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" fill=\"none\" viewBox=\"0 0 13 13\" height=\"13\" width=\"13\"> <circle fill=\"#922694\" r=\"6.5\" cy=\"6.5\" cx=\"6.5\"><\/circle> <\/svg><\/span><\/h2>\n\n\n\n<p class=\"gb-headline gb-headline-8bc749f9 gb-headline-text\">Biomarkers and diagnostic advancements&nbsp;<\/p>\n\n<\/div><\/div>\n<\/div>\n\n\n<a class=\"gb-button gb-button-f9403c3a gb-button-text gb-button-primary button\" href=\"https:\/\/nephcure.org\/about\/our-impact\/grant-opportunities\/nephcure-parasol-grant-program\/\" target=\"_blank\" rel=\"noopener noreferrer\">Learn more<\/a>\n\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-adfed75b\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-b7e9d26b\">\n<div class=\"gb-grid-column gb-grid-column-ffcbc90c\"><div class=\"gb-container gb-container-ffcbc90c\">\n\n<figure class=\"gb-block-image gb-block-image-51d478f4\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-51d478f4\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"Headline decoration line\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-lasting-impact-amp-future-vision-nbsp\" style=\"font-size:25px\"><strong><strong><strong><strong>Lasting Impact &amp; Future Vision<\/strong>&nbsp;<\/strong><\/strong><\/strong><\/h4>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">Through groundbreaking research, critical funding, and an unprecedented spirit of collaboration, the PARASOL Project fundamentally reshaped the landscape of clinical trials for FSGS.&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">By uniting researchers, clinicians, industry leaders, regulators, and patient advocates, the initiative achieved a major milestone: building strong scientific consensus around the use of proteinuria and eGFR as feasible and meaningful surrogate endpoints for clinical trials.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This accomplishment carries far-reaching implications. For FSGS, it means a clearer, faster pathway for evaluating and approving new therapies \u2014 offering renewed hope to patients who urgently need better treatment options. For the broader rare kidney disease community, PARASOL demonstrated that even the most complex research questions can be tackled through rapid, inclusive, data-driven collaboration.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The project&#8217;s success is more than a singular achievement; it establishes a <strong>proven blueprint<\/strong> for the future. The &#8220;PARASOL formula&#8221; \u2014 bringing together global stakeholders, leveraging existing data, and prioritizing practical solutions \u2014 will now serve as a guiding model to accelerate innovation in other rare kidney diseases. Future efforts will build upon the momentum and methodologies pioneered by PARASOL, ensuring that the rare disease community continues to move closer to more effective treatments and, ultimately, cures.&nbsp;<\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-5f18cf75\">\n<div class=\"gb-container gb-container-3bc0ec39\">\n<div class=\"gb-container gb-container-0018102f gb-container-default\">\n\n<figure class=\"gb-block-image gb-block-image-15d37261\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-15d37261\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-33d24afb gb-headline-text\"><strong>External Links to Explore more about PARASOL\u2019s impact in the FSGS space:<\/strong>&nbsp;<\/h2>\n\n\n<div class=\"gb-container gb-container-8a0bd972\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-1ad4621f\">\n<div class=\"gb-grid-column gb-grid-column-823e72cb\"><div class=\"gb-container gb-container-823e72cb\"><a class=\"gb-container-link\" href=\"https:\/\/nephcure.org\/wp-content\/uploads\/2024\/08\/NephCure-Handout-The-Journey-of-RKD-Patients-branded-2.pdf\" rel=\"noopener noreferrer\" target=\"_blank\"><\/a>\n<div class=\"gb-container gb-container-5104685d\"><a class=\"gb-container-link\" href=\"https:\/\/www.kidneynews.org\/view\/journals\/kidney-news\/16\/8\/article-p33_20.xml\" rel=\"noopener noreferrer\" target=\"_blank\"><\/a>\n\n<p class=\"gb-headline gb-headline-653d2d43 gb-headline-text\">KIDNEYNEWS.ORG<\/p>\n\n\n\n<h4 class=\"gb-headline gb-headline-e0f58ce0 gb-headline-text\">PARASOL Effort Progresses to Address Clinical Trial Endpoints in FSGS<\/h4>\n\n<\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-66aaa763\"><div class=\"gb-container gb-container-66aaa763\">\n<div class=\"gb-container gb-container-d7594c67\"><a class=\"gb-container-link\" href=\"https:\/\/investors.zyversa.com\/news-releases\/news-release-details\/zyversa-therapeutics-ceo-issues-shareholder-letter-parasol\" rel=\"noopener noreferrer\" target=\"_blank\"><\/a>\n\n<p class=\"gb-headline gb-headline-91b071ba gb-headline-text\">ZYVERSA.COM<\/p>\n\n\n\n<h4 class=\"gb-headline gb-headline-8f033440 gb-headline-text\">ZyVersa Therapeutics CEO Issues Shareholder Letter on PARASOL Recommendations<\/h4>\n\n<\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-94c697eb\"><div class=\"gb-container gb-container-94c697eb\">\n<div class=\"gb-container gb-container-7678e25a\"><a class=\"gb-container-link\" href=\"https:\/\/announcements.asx.com.au\/asxpdf\/20250428\/pdf\/06j2kvl538gwxv.pdf\" rel=\"noopener noreferrer\" target=\"_blank\"><\/a>\n\n<p class=\"gb-headline gb-headline-faf9c437 gb-headline-text\">DIMERIX<\/p>\n\n\n\n<h4 class=\"gb-headline gb-headline-7049fbb4 gb-headline-text\">FDA Confirms Proteinuria as Acceptable Primary Endpoint<\/h4>\n\n<\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-0863d6c3\"><div class=\"gb-container gb-container-0863d6c3\">\n<div class=\"gb-container gb-container-60b03512\"><a class=\"gb-container-link\" href=\"https:\/\/www.consultantlive.com\/view\/kidney-compass-the-parasol-initiative-with-laura-mariani-md-ms-and-daniel-gale-phd-mb-bchir\" rel=\"noopener noreferrer\" target=\"_blank\"><\/a>\n\n<p class=\"gb-headline gb-headline-8426faa7 gb-headline-text\">CONSULTANTLIVE.COM<\/p>\n\n\n\n<h4 class=\"gb-headline gb-headline-93195915 gb-headline-text\">Kidney Compass: The PARASOL Initiative, with Laura Mariani, MD, MS, and Daniel Gale, PhD, MB BChir<\/h4>\n\n<\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-edef2736\"><div class=\"gb-container gb-container-edef2736\">\n<div class=\"gb-container gb-container-6cbe74ef\"><a class=\"gb-container-link\" href=\"https:\/\/www.kidneynews.org\/view\/journals\/kidney-news\/16\/2\/article-p14_7.xml\" rel=\"noopener noreferrer\" target=\"_blank\"><\/a>\n\n<p class=\"gb-headline gb-headline-5ea5cc51 gb-headline-text\">KIDNEYNEWS.ORG<\/p>\n\n\n\n<h4 class=\"gb-headline gb-headline-ddf2a73a gb-headline-text\">Community Collaborates to Address Clinical Trial Endpoints for FSGS<\/h4>\n\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-42105b23 news-letter-sec alignfull\">\n\n<figure class=\"gb-block-image gb-block-image-b3f3ccb8\"><img loading=\"lazy\" decoding=\"async\" width=\"1920\" height=\"120\" class=\"gb-image gb-image-b3f3ccb8\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/purple-curve.svg\" alt=\"\" title=\"purple-curve\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-41717e70 alignwide\">\n\n<h2 class=\"gb-headline gb-headline-1760ac29 gb-headline-text\">Sign up to get NephCure\u2019s latest updates.<\/h2>\n\n\n\n<a 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