{"id":35752,"date":"2025-05-21T16:28:21","date_gmt":"2025-05-21T20:28:21","guid":{"rendered":"https:\/\/nephcure.org\/?page_id=35752"},"modified":"2025-05-22T17:21:42","modified_gmt":"2025-05-22T21:21:42","slug":"purified-cortrophin-gel","status":"publish","type":"page","link":"https:\/\/nephcure.org\/es\/managing-rkd\/treatment-options\/purified-cortrophin-gel\/","title":{"rendered":"Purified Cortrophin Gel"},"content":{"rendered":"
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Home<\/a><\/span> \/ Managing RKD<\/a><\/span> \/ Treatment Options<\/a><\/span> \/ Purified Cortrophin Gel<\/span><\/span><\/div>\n\n
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Purified Cortrophin Gel<\/h1>\n\n\n\n

Medically reviewed by Dr. Sarah Panzer<\/strong><\/p>\n\n\n\n

A Treatment for Nephrotic Syndrome<\/strong><\/h2>\n\n\n\n

Purified Cortrophin Gel, also known as Cortrophin, is a prescription medication given by injection.   You may also see it referred to as “repository corticotrophin.”  The injection contains a mixture of a hormone (adrenocorticotropic hormone, also called ACTH) and other proteins. ACTH is hormone produced by the pituitary gland.<\/p>\n\n\n\n

Cortrophin was originally approved by the FDA in 1954 and is now approved for 23 indications including some types of nephrotic syndrome. Cortrophin is a treatment used to reduce protein in the urine due to nephrotic syndrome.<\/p>\n\n<\/div>\n<\/section>\n\n

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Nephrotic Syndrome\u00a0<\/strong><\/h2>\n\n\n\n

Cortrophin\u00a0is approved for the treatment of nephrotic syndrome \u2014 a kidney disorder that causes high levels of protein in the urine (proteinuria). It may help reduce proteinuria when other treatments haven\u2019t worked.
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Other FDA-Approved Conditions<\/strong>
Cortrophin\u00a0is also used to treat several other inflammatory and autoimmune conditions, including:
Rheumatoid Arthritis
Lupus
Multiple Sclerosis
Acute Gout\u00a0
Polymyositis
Sarcoidosis
Inflammatory Eye Diseases<\/p>\n\n\n

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Howdoes Purified Cortrophin Ge<\/strong>l work?<\/strong><\/h2>\n\n\n\n

The exact way that Cortrophin works to reduce protein in urine is not known, but research suggests it is by reducing inflammation.\u00a0\u00a0

Cortrophin may:
Stimulate the adrenal glands<\/strong>\u00a0to make more cortisol.\u00a0Cortisol is a hormone that helps regulate the immune system and reduce inflammation.
Target Inflammation<\/strong>\u00a0and immune system dysfunction, which are key factors in nephrotic syndrome.
Act on kidney cell receptors<\/strong>\u00a0involved in nephrotic syndrome, potentially helping to reduce protein leaking into the urine.<\/p>\n\n\n\n

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How is Cortrophin administered?<\/strong><\/h2>\n\n\n\n

Cortrophin\u00a0is injected under the skin or into the muscle.\u00a0\u00a0Cortrophin\u00a0is a gel when refrigerated. At room temperature, it becomes a liquid, ready for injection. It can be shipped to your healthcare provider and administered or it can be shipped to your home and self-administered.\u00a0<\/p>\n\n\n\n

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Is Cortrophin right for me?<\/strong><\/strong><\/h2>\n\n\n\n

Only your nephrologist can determine the right treatment option for you. For patients with nephrotic syndrome whose proteinuria is not well controlled, Cortrophin may be a treatment option.\u00a0\u00a0Cortrophin reduces protein levels in urine for Nephrotic Syndrome patients.\u00a0\u00a0
Learn more about Cortrophin by visiting\u00a0www.cortrophin.com<\/a><\/p>\n\n\n\n

*Note: The decision to prescribe a medication is the responsibility of your physician\/medical team based on their evaluation of your condition. The above is meant for informational purposes only. Discuss this information and all information about drugs\/medications with your physician before starting or stopping any medication.<\/em> <\/p>\n\n<\/div>\n\n

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Frequently Asked Questions<\/h2>\n\n\n
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