{"id":34724,"date":"2024-12-04T15:37:58","date_gmt":"2024-12-04T20:37:58","guid":{"rendered":"https:\/\/nephcure.org\/?page_id=34724"},"modified":"2025-12-11T07:40:22","modified_gmt":"2025-12-11T12:40:22","slug":"complemento-3-glomerulopatia-c3g-ic-mpgn-2","status":"publish","type":"page","link":"https:\/\/nephcure.org\/es\/intro-to-rkd\/types-of-rkd\/complement-3-glomerulopathy-c3g\/","title":{"rendered":"Glomerulopat\u00eda del complemento 3 (C3G)"},"content":{"rendered":"
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Home<\/a><\/span> \/ Intro to RKD<\/a><\/span> \/ Types of RKD<\/a><\/span> \/ Complement 3 Glomerulopathy (C3G)<\/span><\/span><\/div>\n\n
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Complement 3 Glomerulopathy (C3G) <\/strong><\/h1>\n\n\n\n

Complement 3 Glomerulopathy (C3G) is a rare, chronic kidney disease. It damages the glomeruli, the tiny filtering units in the kidneys that help remove toxins from the blood. \u201cComplement 3\u201d (C3) refers to a blood protein that is part of the body\u2019s alternative complement system. The complement system is a group of proteins in the blood that helps the immune system work correctly. Usually, it serves as a first line of defense to protect our bodies from infection. <\/p>\n\n\n\n

C3G occurs when the alternative complement system overactivates. The result is inflammation, glomeruli injury, hematuria (blood in the urine) and proteinuria (protein in the urine). The overactivation of the complement system typically causes chronic kidney damage over time. Approximately half of people with C3G progress to kidney failure in 10 to 15 years. <\/p>\n\n\n\n

Medically reviewed by Dr. Corey Cavanaugh, D.O.<\/em><\/p>\n\n<\/div>\n\n

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Who Gets C3G<\/h3>\n\n\n\n

C3G affects one to two people out of every one million people in the U.S. It can affect people of all ages but typically is diagnosed in people who are in their 20s and 30s.<\/p>\n\n\n\n

Sometimes, genetic changes in specific proteins cause C3G. This is true for about 10 to 25% of people with C3G. Researchers are still studying what causes C3G in other people with the disease. <\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/section>\n\n

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Types of C3G<\/h2>\n\n\n\n

C3G is a specific type of MPGN, of which there are two varieties:<\/p>\n\n\n

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DDD<\/h4>\n\n\n\n

Dense Deposit Disease (DDD)<\/p>\n\n<\/div><\/div>\n\n

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C3GN<\/h4>\n\n\n\n

C3 Glomerulonephritis
(C3GN) <\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n

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Signs and Symptoms<\/h3>\n\n\n
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Some symptoms of C3G include:<\/strong><\/p>\n\n\n\n