{"id":33889,"date":"2024-08-29T11:21:17","date_gmt":"2024-08-29T15:21:17","guid":{"rendered":"https:\/\/nephcure.org\/?page_id=33889"},"modified":"2024-08-29T11:50:12","modified_gmt":"2024-08-29T15:50:12","slug":"budesonida-tarpeyo-2","status":"publish","type":"page","link":"https:\/\/nephcure.org\/es\/managing-rkd\/treatment-options\/fabhalta-iptacopan\/","title":{"rendered":"FABHALTA\u00ae (Iptacopan)\u00a0"},"content":{"rendered":"<section class=\"gb-container gb-container-ba2e2dcb\">\n<div class=\"yoast-breadcrumbs breadcrumb\"><span><span><a href=\"https:\/\/nephcure.org\/\">Home<\/a><\/span> \/ <span><a href=\"https:\/\/nephcure.org\/managing-rkd\/\">Managing RKD<\/a><\/span> \/ <span><a href=\"https:\/\/nephcure.org\/managing-rkd\/treatment-options\/\">Treatment Options<\/a><\/span> \/ <span class=\"breadcrumb_last\" aria-current=\"page\">FABHALTA\u00ae (Iptacopan)\u00a0<\/span><\/span><\/div>\n\n<div class=\"gb-container gb-container-80071c84 hero-copy\">\n\n<h1 class=\"gb-headline gb-headline-6cf43bd0 gb-headline-text hero-content\">FABHALTA\u00ae (Iptacopan)\u00a0<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">FABHALTA\u00ae (Iptacopan) is a recently FDA approved treatment for IgA Nephropathy (IgAN).<\/p>\n\n<\/div>\n\n<div class=\"gb-container gb-container-a6126eda\">\n\n<figure class=\"gb-block-image gb-block-image-40625f55\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-40625f55\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-88096344 gb-headline-text\">How does FABHALTA\u00ae work?<span style=\"caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: -webkit-standard; font-size: medium; font-weight: 400; white-space: normal;\"><\/span><\/h2>\n\n\n\n<p class=\"gb-headline gb-headline-fb79fb92 gb-headline-text\">FABHALTA\u00ae targets the alternative complement pathway in order to lower proteinuria. \u00a0When too many IgA immune complexes are produced and deposited in the kidneys filters, it can activate the complement system which may lead to inflammation and damage to the kidney filters. \u00a0FABHALTA\u00ae binds to Factor B of the alternative complement pathway and helps block the effects of IgA Nephropathy on the kidneys.<\/p>\n\n\n<div class=\"gb-container gb-container-626eb763\"><\/div>\n\n\n<figure class=\"gb-block-image gb-block-image-8e308869\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-8e308869\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-3de92b95 gb-headline-text\">What does the research say about FABHALTA\u00ae?<span style=\"caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: -webkit-standard; font-size: medium; font-weight: 400; white-space: normal;\"><\/span><\/h2>\n\n\n\n<p class=\"gb-headline gb-headline-fd1cb896 gb-headline-text\">FABHALTA\u00ae has been studied in clinical trials specifically for IgAN. \u00a0The clinical trials compared patients prescribed FABHALTA\u00ae with blood pressure medications and\/or SGLT2 inhibitors to patients taking placebo (non-active medication) with blood pressure medications and\/or SGLT2 inhibitors. \u00a0The patients prescribed FABHALTA\u00ae had up to 44% lower levels of protein in their urine after 9 months.<\/p>\n\n\n\n<figure class=\"gb-block-image gb-block-image-67fe5e06\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-67fe5e06\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-da1ae61d gb-headline-text\"><strong>What kind of medication is FABHALTA\u00ae?<\/strong><span style=\"caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-family: -webkit-standard; font-size: medium; font-weight: 400; white-space: normal;\"><\/span><\/h2>\n\n\n\n<p class=\"gb-headline gb-headline-c164ace3 gb-headline-text\">FABHALTA\u00ae is an oral treatment (taken by mouth) two times a day. It is a class of medication called complement inhibitors that targets Factor B of the alternative complement pathway in order to reduce protein in the urine in adults. It is not known if FABHALTA\u00ae is safe and effective in children with IgAN.\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>*Note: The decision to prescribe a medication is the responsibility of your physician\/medical team based on their evaluation of your condition. The above is meant for informational purposes only. Discuss this information and all information about drugs\/medications with your physician before starting or stopping any medication.<\/em>&nbsp;<\/p>\n\n<\/div>\n<\/section>\n\n<div class=\"gb-container gb-container-80f48e60\">\n\n<figure class=\"gb-block-image gb-block-image-639c7bd5\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-639c7bd5\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-bff6dfde gb-headline-text\">Frequently Asked Questions<\/h2>\n\n\n<div class=\"gb-container gb-container-3f003111 gb-accordion\">\n<div class=\"gb-container gb-container-342c972d gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-05b57231 gb-accordion__toggle\" id=\"gb-accordion-toggle-05b57231\"><span class=\"gb-button-text\">What are the side effects of FABHALTA\u00ae?<\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" width=\"1em\" height=\"1em\" ariahidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" width=\"1em\" height=\"1em\" ariahidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-f9fdcd74\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-f9fdcd74\">\n\n<p class=\"wp-block-paragraph\"><strong>The most common side effects of FABHALTA\u00ae may include:<br><\/strong>\u2022 Headache<br>\u2022 Nasal congestion, runny nose, cough, sneezing, and sore throat<br>\u2022 Diarrhea<br>\u2022 Stomach pain<br>\u2022 Nausea<br>\u2022 Infections\u00a0<br>\u2022 Rash<br><br><br><strong>FABHALTA\u00ae may cause serious side effects including:<br><\/strong>\u2022 Serious infections caused by encapsulated bacteria<br>\u2022 Increased cholesterol and triglyceride (lipid) levels in your blood.<br>\u00a0<br><em>See what I should know before taking FABHALTA\u00ae for more information regarding side effect management while taking FABHALTA\u00ae.\u00a0<\/em><\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-68f0eaa5 gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-d702eeea gb-accordion__toggle\" id=\"gb-accordion-toggle-d702eeea\"><span class=\"gb-button-text\">What should I know before taking FABHALTA\u00ae?<\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" width=\"1em\" height=\"1em\" ariahidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" width=\"1em\" height=\"1em\" ariahidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-2b8161d3\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-2b8161d3\">\n\n<p class=\"wp-block-paragraph\"><strong>Some things to consider while taking FABHALTA\u00ae include:<br><\/strong>\u2022 FABHALTA\u00ae may be prescribed with other medications, such as blood pressure medication. \u00a0Be\u00a0<br>sure to discuss with your nephrologist the best treatment plan and options for you.<br>\u2022 FABHALTA\u00ae is a medicine that affects part of your immune system and may lower your ability to fight infections.\u00a0<br>\u2022 FABHALTA\u00ae is only available through a program called FABHALTA\u00ae Risk Evaluation and Mitigation Strategy (REMS) and your doctor must counsel you about the risk of serious infections caused by certain bacteria and make sure you are vaccinated against serious infections caused by encapsulated bacteria, and give you a Patient Safety Card. The FABHALTA\u00ae REMS program is designed to keep you safe and mitigate potential harmful side effects.<br>\u2022 FABHALTA\u00ae is approved based on a reduction of proteinuria. Continued approval may require results from an ongoing study to determine whether FABHALTA\u00ae slows the decline in kidney function.<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-2fcf7640 gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-69efb835 gb-accordion__toggle\" id=\"gb-accordion-toggle-69efb835\"><span class=\"gb-button-text\"><strong>What <\/strong>Should I tell my doctor before I consider taking <strong>FABHALTA\u00ae<\/strong>?<\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" width=\"1em\" height=\"1em\" ariahidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" width=\"1em\" height=\"1em\" ariahidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div id=\"gb-accordion-content-7a4bb49d\" class=\"gb-accordion__content\"><div class=\"gb-container gb-container-7a4bb49d\">\n\n<p class=\"wp-block-paragraph\"><strong>Before you take FABHALTA\u00ae tell your doctor if you:<br><\/strong>\u2022 Have an infection or fever<br>\u2022 Have liver problems<br>\u2022 Are pregnant or plan to become pregnant or are breastfeeding as it is not known if FABHALTA\u00ae will harm your unborn baby.<\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-0d21e4ac\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-3d338a55\">\n<div class=\"gb-grid-column gb-grid-column-296a2c84\"><div class=\"gb-container gb-container-296a2c84\">\n<div class=\"gb-container gb-container-eb83049f\">\n\n<h2 class=\"gb-headline gb-headline-5127a4de gb-headline-text\">Find a Specialist<\/h2>\n\n\n\n<p class=\"gb-headline gb-headline-00d5119d gb-headline-text\">It is important to work with a nephrologist who specializes in rare kidney disease (RKD) and can provide personalized advice based on your individual health needs and changes in available treatments. NephCure has a curated list of NephCure Specialists nationwide ready to help you.<\/p>\n\n<\/div>\n\n<div class=\"gb-container gb-container-54aa31c0\"><a class=\"gb-container-link\" href=\"https:\/\/nephcure.org\/managing-rkd\/find-a-specialist\/\"><\/a>\n\n<p class=\"gb-headline gb-headline-38137575\"><span class=\"gb-icon\"><svg fill=\"none\" viewBox=\"0 0 27 24\" height=\"24\" width=\"27\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"> <path fill=\"#00556B\" d=\"M26.0607 13.0607C26.6464 12.4749 26.6464 11.5251 26.0607 10.9393L16.5147 1.3934C15.9289 0.807611 14.9792 0.807611 14.3934 1.3934C13.8076 1.97919 13.8076 2.92893 14.3934 3.51472L22.8787 12L14.3934 20.4853C13.8076 21.0711 13.8076 22.0208 14.3934 22.6066C14.9792 23.1924 15.9289 23.1924 16.5147 22.6066L26.0607 13.0607ZM0 13.5H25V10.5H0V13.5Z\"><\/path> <\/svg><\/span><\/p>\n\n<\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-00512214\"><div class=\"gb-container gb-container-00512214\">\n<div class=\"gb-container gb-container-178632bb\">\n\n<h2 class=\"gb-headline gb-headline-74b009b0 gb-headline-text\">Clinical Trials<\/h2>\n\n\n\n<p class=\"has-secondary-lighter-gray-color has-text-color has-link-color wp-elements-6bb4aec7a7f561f2b664a676c9d49fc4 wp-block-paragraph\">From accessing cutting-edge treatments to being part of groundbreaking research, discover the benefits that can make a real difference. Learn more about clinical trials currently taking place, and find opportunities near you.<\/p>\n\n<\/div>\n\n<div class=\"gb-container gb-container-e263f928\"><a class=\"gb-container-link\" href=\"https:\/\/nephcure.org\/managing-rkd\/clinical-trials\/\"><\/a>\n\n<p class=\"gb-headline gb-headline-7dbd95e4\"><span class=\"gb-icon\"><svg fill=\"none\" viewBox=\"0 0 27 24\" height=\"24\" width=\"27\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"> <path fill=\"#00556B\" d=\"M26.0607 13.0607C26.6464 12.4749 26.6464 11.5251 26.0607 10.9393L16.5147 1.3934C15.9289 0.807611 14.9792 0.807611 14.3934 1.3934C13.8076 1.97919 13.8076 2.92893 14.3934 3.51472L22.8787 12L14.3934 20.4853C13.8076 21.0711 13.8076 22.0208 14.3934 22.6066C14.9792 23.1924 15.9289 23.1924 16.5147 22.6066L26.0607 13.0607ZM0 13.5H25V10.5H0V13.5Z\"><\/path> <\/svg><\/span><\/p>\n\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-42105b23 news-letter-sec alignfull\">\n\n<figure class=\"gb-block-image gb-block-image-b3f3ccb8\"><img loading=\"lazy\" decoding=\"async\" width=\"1920\" height=\"120\" class=\"gb-image gb-image-b3f3ccb8\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/purple-curve.svg\" alt=\"\" title=\"purple-curve\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-41717e70 alignwide\">\n\n<h2 class=\"gb-headline gb-headline-1760ac29 gb-headline-text\">Sign up to get NephCure\u2019s latest updates.<\/h2>\n\n\n\n<a class=\"gb-button gb-button-753f318a gb-button-text gb-button-primary button\" href=\"\/newsletter\/\">SIGN UP<\/a>\n\n\n<div class=\"gb-container gb-container-2b968bcb news-letter-field\">\n    <script type=\"text\/javascript\">\n    jQuery(document).ready(function($) {\n        const disposableDomains = [\n            'mailinator.com', 'yopmail.com', 'tempmail.com', 'guerrillamail.com',\n            'throwawaymail.com', 'fakeinbox.com', 'trashmail.com', 'sharklasers.com',\n            'tempinbox.com', '10minutemail.com'\n        ];\n        const majorProviders = [\n            'gmail.com', 'yahoo.com', 'hotmail.com', 'outlook.com',\n            'aol.com', 'icloud.com', 'protonmail.com'\n        ];\n        const suspiciousUsernames = [\n            'test', 'example', 'user', 'admin', 'info', 'mail', 'email',\n            'noreply', 'no-reply', 'donotreply', 'do-not-reply', 'fake',\n            'abc', '123', 'xyz', 'asdf', 'qwerty', 'demo', 'sample',\n            'spam', 'temp', 'dummy', 'foobar', 'anonymous', 'disposable'\n        ];\n        const keyboardPatterns = ['qwerty', 'asdfgh', 'zxcvbn', '123456'];\n\n        function isValidEmailFormat(email) {\n            const regex = \/^[^\\s@]+@[^\\s@]+\\.[^\\s@]+$\/;\n            return regex.test(email);\n        }\n\n        function hasSuspiciousPattern(username) {\n            if (suspiciousUsernames.includes(username)) return true;\n            if (username.length <= 2) return true;\n            if (\/^(.)\\1{3,}$\/.test(username)) return true;\n            for (const pattern of keyboardPatterns) {\n                if (username.includes(pattern)) return true;\n            }\n            return false;\n        }\n\n        function usernameMatchesDomain(username, domain) {\n            const domainBase = domain.split('.')[0];\n            return username === domainBase;\n        }\n\n        $('.ginput_container_email input').on('blur', function() {\n            const emailField = $(this);\n            const email = emailField.val().trim().toLowerCase();\n            const errorContainer = emailField.siblings('.validation_message');\n\n            \/\/ Clear any previous messages\n            if (errorContainer.length) errorContainer.remove();\n            emailField.removeClass('gfield_error gfield_warning');\n\n            if (email === '') return;\n\n            const username = email.substring(0, email.lastIndexOf('@'));\n            const domain = email.substring(email.lastIndexOf('@') + 1);\n\n            if (!isValidEmailFormat(email)) {\n                emailField.after('<div class=\"validation_message\">Please enter a valid email address.<\/div>');\n                emailField.addClass('gfield_error');\n                return;\n            }\n\n            if (disposableDomains.includes(domain)) {\n                emailField.after('<div class=\"validation_message\">Disposable email addresses are not allowed.<\/div>');\n                emailField.addClass('gfield_error');\n                return;\n            }\n\n            if (usernameMatchesDomain(username, domain)) {\n                emailField.after('<div class=\"validation_message\">This email looks suspicious (username matches domain). 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