{"id":29189,"date":"2024-04-18T14:59:40","date_gmt":"2024-04-18T18:59:40","guid":{"rendered":"https:\/\/nephcure.org\/?page_id=29189"},"modified":"2026-03-17T11:08:48","modified_gmt":"2026-03-17T15:08:48","slug":"programa-de-becas-para-estudios-auxiliares-nephcure-neptune","status":"publish","type":"page","link":"https:\/\/nephcure.org\/es\/about\/our-impact\/grant-opportunities\/pilot-grant-program\/","title":{"rendered":"NephCure \u2013 Programa piloto de subvenciones"},"content":{"rendered":"<section class=\"gb-container gb-container-ba2e2dcb\">\n<div class=\"yoast-breadcrumbs breadcrumb\"><span><span><a href=\"https:\/\/nephcure.org\/\">Home<\/a><\/span> \/ <span><a href=\"https:\/\/nephcure.org\/about\/\">About<\/a><\/span> \/ <span><a href=\"https:\/\/nephcure.org\/about\/our-impact\/\">Our Impact<\/a><\/span> \/ <span><a href=\"https:\/\/nephcure.org\/about\/our-impact\/grant-opportunities\/\">Grant Opportunities<\/a><\/span> \/ <span class=\"breadcrumb_last\" aria-current=\"page\">NephCure &#8211; Pilot Grant Program<\/span><\/span><\/div>\n\n<div class=\"gb-container gb-container-80071c84 hero-copy\">\n\n<h1 class=\"gb-headline gb-headline-6cf43bd0 gb-headline-text hero-content\">NephCure &#8211; Pilot Grant Program<\/h1>\n\n<\/div>\n\n<div class=\"gb-container gb-container-ed52396b\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-08dc723e\">\n<div class=\"gb-grid-column gb-grid-column-9ac4bc49\"><div class=\"gb-container gb-container-9ac4bc49\">\n\n<figure class=\"gb-block-image gb-block-image-b652c693\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-b652c693\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"Headline decoration line\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-objectives\" style=\"font-size:25px\"><strong><strong>Objectives<\/strong><\/strong><\/h3>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">NephCure announces a research grant program to support investigator-initiated studies that employ CureGN and or NEPTUNE resources to advance clinical and translational research in glomerular disease. The program is open to&nbsp;all scientists, including those within and outside of the CureGN or NEPTUNE Consortia. Proposed projects can include, but are not limited to, those that can be used to generate feasibility data to support advancement of promising future studies and projects to develop clinical assays, or protocols, or early phase clinical trials. NephCure will provide funding of up to $250,000 direct cost per project ($125,000 per year per project over a two-year time period, for two total projects) after a competitive process to select the most meritorious projects. Wherever possible, proposals should adhere to the guiding principles of NEPTUNE and CureGN:<\/p>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-7cd2dee9\"><div class=\"gb-container gb-container-7cd2dee9\">\n\n<figure class=\"gb-block-image gb-block-image-f3469e34\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" class=\"gb-image gb-image-f3469e34\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2024\/03\/2-1024x576.png\" alt=\"\" title=\"2 kidney\" srcset=\"https:\/\/nephcure.org\/wp-content\/uploads\/2024\/03\/2-1024x576.png 1024w, https:\/\/nephcure.org\/wp-content\/uploads\/2024\/03\/2-300x169.png 300w, https:\/\/nephcure.org\/wp-content\/uploads\/2024\/03\/2-768x432.png 768w, https:\/\/nephcure.org\/wp-content\/uploads\/2024\/03\/2-1536x864.png 1536w, https:\/\/nephcure.org\/wp-content\/uploads\/2024\/03\/2-18x10.png 18w, https:\/\/nephcure.org\/wp-content\/uploads\/2024\/03\/2.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n<ol class=\"wp-block-list\">\n<li>Collaboration: among participants within the Consortia and between the Consortia and external investigators conducting a pilot or ancillary studies using Consortium resources, is essential to the success of the program.<\/li>\n\n\n\n<li>Integration: NephCure and the NEPTUNE and CureGN Consortia understand&#8211;and will take advantage of&#8211;the dramatic benefits to advancing glomerular disease science inherent in employing a multi-disciplinary approach.<\/li>\n\n\n\n<li>Sharing: NEPTUNE and CureGN will serve as a resource to the community of scientists and lay persons interested in studying glomerular disease. NEPTUNE and CureGN\u2019s ability to share systematically collected data, biospecimens, and infrastructure for future ancillary studies is as important to advancing this field as studies conducted directly by the Consortia.<\/li>\n\n\n\n<li>Networking: the existence and experience of maintaining a network of investigators and clinical study sites with experience in glomerular disease research will dramatically facilitate organizing and conducting future clinical studies by investigators in the public and private sector.<\/li>\n<\/ol>\n\n\n<div class=\"gb-container gb-container-3dd326cd gb-container-default\">\n\n<figure class=\"gb-block-image gb-block-image-f04b9551\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-f04b9551\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h3 class=\"gb-headline gb-headline-a237975b gb-headline-text\"><strong>Meritorious Characteristics<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Pilot project proposals will be evaluated for their compliance with the guiding principles described above. The following project characteristics will be considered meritorious if:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>The project utilizes the unique CureGN or NEPTUNE clinical data, biomaterials, infrastructure, resources and\/or contributes by adding to these resources in a collaborative manner for the advancement of the work of others within the Consortia.<\/li>\n\n\n\n<li>The project requires and benefits from the collaboration of individuals within CureGN or NEPTUNE Consortia and external investigators.<\/li>\n\n\n\n<li>The project integrates scientific disciplines to advance glomerular disease research.<\/li>\n\n\n\n<li>The project shares new data, biological specimens, and\/or infrastructure that may result from the project with the Consortium and its collaborating investigators.<\/li>\n<\/ol>\n\n<\/div>\n\n<div class=\"gb-container gb-container-884e10b6 gb-container-default\">\n\n<figure class=\"gb-block-image gb-block-image-b9f96c05\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-b9f96c05\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h3 class=\"gb-headline gb-headline-c19d8fc6 gb-headline-text\"><strong>Eligibility<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">CureGN and\/or NEPTUNE participant investigators and their collaborators&nbsp;<strong>OR<\/strong>&nbsp;scientists presently unaffiliated with CureGN or NEPTUNE.&nbsp;&nbsp;We are accepting applications from national and international institutions.&nbsp;&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Applicants are&nbsp;required&nbsp;to leverage the resources provided by CureGN\/NEPTUNE (infrastructure, accumulated human subjects and their associated data and materials) by bringing additional resources to conducting proposed investigations.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">NephCure maintains pilot project grant programs that require the use of either CureGN&nbsp;or&nbsp;NEPTUNE or both consortium resources.&nbsp;&nbsp;&nbsp;<\/p>\n\n<\/div>\n\n<div class=\"gb-container gb-container-2954350b gb-container-default\">\n\n<figure class=\"gb-block-image gb-block-image-be41aeda\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-be41aeda\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h3 class=\"gb-headline gb-headline-397c3df9 gb-headline-text\"><strong>Funding<\/strong><\/h3>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Projects will be funded directly by NephCure to the recipient institutions.<\/strong><\/li>\n\n\n\n<li>Applicants may request up to&nbsp;<strong>$250,000 per project in direct costs only, paid over a 2-year period or $125,000 per year.<\/strong><\/li>\n\n\n\n<li><strong>No indirect costs allowed<\/strong>. NephCure has a long-standing policy to support direct costs only.<\/li>\n\n\n\n<li>Projects are <strong>funded for 24 months<\/strong>, with a start date no earlier than January 2028.<\/li>\n\n\n\n<li>This <strong>program offers up to $500,000 in FY2028<\/strong> for this grant program, to be paid out over two years. The number of projects funded will be dictated by the size of project budgets requested and awarded. NephCure makes this determination at the time of review.<\/li>\n<\/ol>\n\n<\/div>\n\n<div class=\"gb-container gb-container-0746e55c gb-container-default\">\n\n<figure class=\"gb-block-image gb-block-image-a0d2cce4\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-a0d2cce4\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h3 class=\"gb-headline gb-headline-85518750 gb-headline-text\"><strong>Application\/Review Process<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The process of submitting applications to NephCure for this pilot grant program will occur following the deadlines listed below. Pilot project applications must propose using resources from either NEPTUNE, CureGN or both consortia. For this reason, no application can be submitted to NephCure before approval of a joint CureGN or NEPTUNE Ancillary Study Review Committee and the CureGN and\/or NEPTUNE Steering Committees. This process helps evaluate proposals for burden to NEPTUNE and\/or CureGN Consortia, their study subjects, and their biosamples.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Please follow the following process in submitting applications:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Applicants are encouraged to discuss study feasibility and impact of the proposed study on the consortium with consortia investigators or support staff. Prospective applicants may contact the project management team at \u2013&nbsp;<strong><u>NephCurePilotGrant@med.umich.edu<\/u><\/strong>&nbsp;for referral to individuals who can help.&nbsp;&nbsp;This contact email should be used by those using both CureGN and\/or NEPTUNE applications.&nbsp;Working with the DCC and prior to submission of ancillary study applications, applicants should understand the scope and scale of the datasets to establish study feasibility.<\/li>\n\n\n\n<li>Submit a Letter of Intent: Applicants must submit a short, one-page description of the proposed study using the template attached by the deadline below. An ad hoc review committee comprised of NEPTUNE and CureGN investigators will evaluate and prioritize Letters of Intent and will invite a maximum of 12 applicants to continue the application process.&nbsp;<\/li>\n\n\n\n<li>Invited CureGN\/NEPTUNE Ancillary Study Proposal: Those invited will be asked to submit a formal NEPTUNE\/CureGN ancillary study proposal by the deadline below (see attachment below). These proposals will be reviewed by the Consortia Ancillary Studies Committee (ASC) for the purpose of determining whether the project represents an acceptable burden to NEPTUNE\/CureGN subjects, its dataset, and its infrastructure. Final approval for all Consortia ancillary studies resides with the Steering Committee prior to submission for external funding.<\/li>\n\n\n\n<li>Grant Application Submission to NephCure: Applicants will be informed once NEPTUNE\/CureGN ancillary study approval is obtained, and will be invited to complete formal proposal applications that will be submitted to NephCure for competitive review. NephCure is responsible for funding decisions. NephCure will assemble a formal peer-review committee (with no more than two CureGN or NEPTUNE investigator participants), evaluate proposals, and assign a priority score that will be used by the NephCure Research Committee in reaching funding decisions. The goal of this process is to identify the most meritorious ancillary study proposals prioritized based on the:<\/li>\n<\/ol>\n\n\n<div class=\"gb-container gb-container-8ba690ea\">\n\n<ul class=\"wp-block-list\">\n<li>Potential scientific impact of the project consistent with the collective mission of NephCure, CureGN, and\/or NEPTUNE;<\/li>\n\n\n\n<li>Scientific significance and\/or novelty of the proposed hypothesis;<\/li>\n\n\n\n<li>Feasibility of the project;<\/li>\n\n\n\n<li>Impact of the project to the care of glomerular disease patients.<\/li>\n<\/ul>\n\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><strong>Just in Time Approval by Applicant\u2019s IRB&nbsp;\u2013 if required by the nature of the project, funding will be provided when IRB approval is in place, or when IRB approval is granted pending funding. IRB approval is not necessary prior to application.<\/strong><\/p>\n\n<\/div>\n\n<div class=\"gb-container gb-container-8ec9dd8c gb-container-default\">\n\n<figure class=\"gb-block-image gb-block-image-53526db5\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-53526db5\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h3 class=\"gb-headline gb-headline-2289cace gb-headline-text\"><strong>Review Timeline<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Deadline for submission of Letter of Intent to apply: January 15, 2027<\/strong>. Please contact, Project Management, at\u00a0<a href=\"mailto:NephCurePilotGrant@med.umich.edu\">NephCurePilotGrant@med.umich.edu<\/a>\u00a0for details.\u00a0 The CureGN and NEPTUNE websites can also be helpful as you begin thinking about this project.\u00a0 [CureGN.org\u00a0and\u00a0NEPTUNE-study.org] We strongly recommend commencing this discussion as soon as possible.<\/p>\n\n<\/div>\n\n<div class=\"gb-container gb-container-998f818d gb-container-default\">\n\n<figure class=\"gb-block-image gb-block-image-f4806afb\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-f4806afb\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h3 class=\"gb-headline gb-headline-2257b735 gb-headline-text\"><strong>Important Dates<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Deadline for Letter of Intent\/Concept Sheet:<strong>&nbsp;January 15, 2027<\/strong><\/li>\n\n\n\n<li>Deadline for receipt of final Ancillary Study Application:&nbsp;<strong>March 19, 2027<\/strong><\/li>\n\n\n\n<li><strong>Deadline for application to NephCure: July 16, 2027, 8 PM Eastern Time (no exceptions)<\/strong><\/li>\n\n\n\n<li><strong>Announcement of preliminary intent to award project: October, 2027<\/strong><\/li>\n\n\n\n<li>Completion of Just-In-Time process (necessary IRB approval\/amendment):&nbsp;<strong>December, 2027<\/strong><\/li>\n\n\n\n<li>Project Start Date:&nbsp;<strong>January, 2028<\/strong><\/li>\n<\/ul>\n\n<\/div>\n\n<div class=\"gb-container gb-container-62e83871 gb-container-default\">\n\n<figure class=\"gb-block-image gb-block-image-d7ffb46c\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-d7ffb46c\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h3 class=\"gb-headline gb-headline-f69679d2 gb-headline-text\"><strong>Final NephCure Application Format<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Except where noted, applicants should use the NIH Form 398 application form and complete all items on indicated forms following 398 form instructions. (<a href=\"http:\/\/grants1.nih.gov\/grants\/funding\/phs398\/phs398.html\" target=\"_blank\" rel=\"noreferrer noopener\">http:\/\/grants1.nih.gov\/grants\/funding\/phs398\/phs398.html<\/a>)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Please use the following checklist:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>\u2014<\/td><td>Face Page (signature from institutional representative required)<\/td><\/tr><tr><td>\u2014<\/td><td>Abstract (398 Form Page 2)<\/td><\/tr><tr><td>\u2014<\/td><td>Budget (398 Form Page 4\u2014a modular budget should&nbsp;<strong>not<\/strong>&nbsp;be used)<\/td><\/tr><tr><td><\/td><td>Include a description of how additional resources obtained outside this grant, if any, will be used to leverage support (if appropriate, attach support documentation)<\/td><\/tr><tr><td>\u2014<\/td><td>Biographical sketch \u2013 PI and key personnel (398 Format; please employ newly revised NIH format)<\/td><\/tr><tr><td>\u2014<\/td><td>Resources (398 Format)<\/td><\/tr><tr><td>\u2014<\/td><td>Research Plan \u2013 The following format should be employed<\/td><\/tr><tr><td><\/td><td>&#8211; Specific Aims<br>&#8211; Background and Significance<br>&#8211; Preliminary Data, if any<br>&#8211; Research Design<br>&#8211; Include description of how resources of CureGN and\/or NEPTUNE will be leveraged in completing the proposed studies<br>&#8211; Include a discussion of how the project or the data generated might be employed\/shared by other consortium investigators or how the consortium or its participating investigators might benefit from this project<br>&#8211; Include description of how this \u201cpilot\u201d project will be parlayed into a complete project<br>&#8211; If an interventional trial is being proposed, the application should discuss how the proposed trial will be integrated into the existing observational protocol<br>&#8211; Include timeline<br>&#8211; Include Literature Cited<br>&#8211; Include one paragraph summary describing how the research design employs the \u201cmeritorious characteristics\u201d described above<br><strong>Page limit:<\/strong>&nbsp;5 pages&nbsp;for entire Research Plan. This page limit includes figures and tables. Literature Cited is not included in these limits.<\/td><\/tr><tr><td>\u2014<\/td><td>Sharing Plan:<\/td><\/tr><tr><td><\/td><td>Sharing Plan \u2013 Please provide a statement that you will impose no restrictions in sharing data or reagents generated by this project in accordance with the NephCure and Consortia Policy<\/td><\/tr><tr><td>\u2014<\/td><td>Letters of Support:<\/td><\/tr><tr><td><\/td><td>From co-investigators and\/or committing to additional support (institutional or other), if any<\/td><\/tr><tr><td>\u2014<\/td><td>Study protocol may be included with initial application or may be provided after announcement of intent to fund and before vetting by the Ancillary Studies Committee and IRB<\/td><\/tr><tr><td>\u2014<\/td><td>No other appendix&nbsp;of any type permitted<\/td><\/tr><tr><td>\u2014<\/td><td><strong>Formatting requirements:<\/strong><\/td><\/tr><tr><td>\u2014<\/td><td>Applicants&nbsp;must&nbsp;use an 11 pt Arial font and \u00bd-inch margins and cannot exceed length restrictions described above; this will be&nbsp;strictly&nbsp;enforced; must be written in English language. Applications that fail to comply with this format will be returned to the applicant without review.<\/td><\/tr><tr><td>\u2014<\/td><td><strong>Grant submission:<\/strong><\/td><\/tr><tr><td><\/td><td>All applications should be compiled into a single pdf format document that can be read using the Adobe Reader or Acrobat application. Formal grant applications should be emailed to Rebecca \u201cBirdie\u201d Cook at&nbsp;<a href=\"mailto:rcook@nephcure.org\"><strong><u>rcook@nephcure.org<\/u><\/strong><\/a>. Please place \u201cNephCure-Pilot grant applic\/Your last name\u201d in the subject line. If you are preparing a project using CureGN and NEPTUNE data, please edit the name of your saved grant application to reflect this. If you are using just one data\/sample set, please use that name. A receipt will be provided on the following day.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"gb-block-image gb-block-image-eddb19bd\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-eddb19bd\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\"\/><\/figure>\n\n\n\n<h3 class=\"gb-headline gb-headline-c607456e gb-headline-text\"><strong>Terms of Support<\/strong><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Funds (direct costs only) are provided to investigator\u2019s institution for use by the applicant; it is the applicant institution\u2019s obligation to ensure proper use of funds and timely submission of progress reports.<\/li>\n\n\n\n<li>Disbursal of grant funds will be made in quarter-annual payments at the end of each fiscal quarter. Final payments will be made only after receipt of a final progress report that is due no later than 30 days following the last day of the project. NephCure does not support no-cost extensions.<\/li>\n\n\n\n<li>Principal investigators must comply with human institutional review board requirements and demonstrate current approval of these committees.<\/li>\n\n\n\n<li>Reporting requirements: Principal investigators must provide an annual report due no later than 30-days after the first and second year of funding describing progress made during the previous year. Failure to provide this report in a timely manner may result in reduction in payment.<\/li>\n\n\n\n<li>It is expected that results obtained will be shared with the consortium in a manner consistent with the ancillary studies policies of CureGN and NEPTUNE.<\/li>\n\n\n\n<li>It is expected that publications will be submitted in compliance with the publications policies of CureGN and\/or NEPTUNE.<\/li>\n\n\n\n<li>NephCure and NIH support of ancillary studies will be acknowledged by grantees in publications, presentations, abstracts and other relevant press releases and on associated websites.<\/li>\n\n\n\n<li>CureGN, NEPTUNE, and associated investigators do not discriminate based on race, gender, religious, or ethnic group; applicants should assure compliance with this policy in designing and executing their studies.<\/li>\n<\/ul>\n\n<\/div>\n<\/section>\n\n<div class=\"gb-container gb-container-42105b23 news-letter-sec alignfull\">\n\n<figure class=\"gb-block-image gb-block-image-b3f3ccb8\"><img loading=\"lazy\" decoding=\"async\" width=\"1920\" height=\"120\" class=\"gb-image gb-image-b3f3ccb8\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/purple-curve.svg\" alt=\"\" title=\"purple-curve\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-41717e70 alignwide\">\n\n<h2 class=\"gb-headline gb-headline-1760ac29 gb-headline-text\">Sign up to get NephCure\u2019s latest updates.<\/h2>\n\n\n\n<a class=\"gb-button gb-button-753f318a gb-button-text gb-button-primary button\" href=\"\/newsletter\/\">SIGN UP<\/a>\n\n\n<div class=\"gb-container gb-container-2b968bcb news-letter-field\">\n    <script type=\"text\/javascript\">\n    jQuery(document).ready(function($) {\n        const disposableDomains = [\n            'mailinator.com', 'yopmail.com', 'tempmail.com', 'guerrillamail.com',\n            'throwawaymail.com', 'fakeinbox.com', 'trashmail.com', 'sharklasers.com',\n            'tempinbox.com', '10minutemail.com'\n        ];\n        const majorProviders = [\n            'gmail.com', 'yahoo.com', 'hotmail.com', 'outlook.com',\n            'aol.com', 'icloud.com', 'protonmail.com'\n        ];\n        const suspiciousUsernames = [\n            'test', 'example', 'user', 'admin', 'info', 'mail', 'email',\n            'noreply', 'no-reply', 'donotreply', 'do-not-reply', 'fake',\n            'abc', '123', 'xyz', 'asdf', 'qwerty', 'demo', 'sample',\n            'spam', 'temp', 'dummy', 'foobar', 'anonymous', 'disposable'\n        ];\n        const keyboardPatterns = ['qwerty', 'asdfgh', 'zxcvbn', '123456'];\n\n        function isValidEmailFormat(email) {\n            const regex = \/^[^\\s@]+@[^\\s@]+\\.[^\\s@]+$\/;\n            return regex.test(email);\n        }\n\n        function hasSuspiciousPattern(username) {\n            if (suspiciousUsernames.includes(username)) return true;\n            if (username.length <= 2) return true;\n            if (\/^(.)\\1{3,}$\/.test(username)) return true;\n            for (const pattern of keyboardPatterns) {\n                if (username.includes(pattern)) return true;\n            }\n            return false;\n        }\n\n        function usernameMatchesDomain(username, domain) {\n            const domainBase = domain.split('.')[0];\n            return username === domainBase;\n        }\n\n        $('.ginput_container_email input').on('blur', function() {\n            const emailField = $(this);\n            const email = emailField.val().trim().toLowerCase();\n            const errorContainer = emailField.siblings('.validation_message');\n\n            \/\/ Clear any previous messages\n            if (errorContainer.length) errorContainer.remove();\n            emailField.removeClass('gfield_error gfield_warning');\n\n            if (email === '') return;\n\n            const username = email.substring(0, email.lastIndexOf('@'));\n            const domain = email.substring(email.lastIndexOf('@') + 1);\n\n            if (!isValidEmailFormat(email)) {\n                emailField.after('<div class=\"validation_message\">Please enter a valid email address.<\/div>');\n                emailField.addClass('gfield_error');\n                return;\n            }\n\n            if (disposableDomains.includes(domain)) {\n                emailField.after('<div class=\"validation_message\">Disposable email addresses are not allowed.<\/div>');\n                emailField.addClass('gfield_error');\n                return;\n            }\n\n            if (usernameMatchesDomain(username, domain)) {\n                emailField.after('<div class=\"validation_message\">This email looks suspicious (username matches domain). 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