{"id":29188,"date":"2024-04-18T14:24:26","date_gmt":"2024-04-18T18:24:26","guid":{"rendered":"https:\/\/nephcure.org\/?page_id=29188"},"modified":"2025-09-30T15:12:44","modified_gmt":"2025-09-30T19:12:44","slug":"programa-de-subvenciones-para-sombrillas-nephcure","status":"publish","type":"page","link":"https:\/\/nephcure.org\/es\/about\/our-impact\/grant-opportunities\/nephcure-parasol-grant-program\/","title":{"rendered":"NephCure \u2013 Programa de subvenciones PARASOL"},"content":{"rendered":"<section class=\"gb-container gb-container-ba2e2dcb\">\n<div class=\"yoast-breadcrumbs breadcrumb\"><span><span><a href=\"https:\/\/nephcure.org\/\">Home<\/a><\/span> \/ <span><a href=\"https:\/\/nephcure.org\/about\/\">About<\/a><\/span> \/ <span><a href=\"https:\/\/nephcure.org\/about\/our-impact\/\">Our Impact<\/a><\/span> \/ <span><a href=\"https:\/\/nephcure.org\/about\/our-impact\/grant-opportunities\/\">Grant Opportunities<\/a><\/span> \/ <span class=\"breadcrumb_last\" aria-current=\"page\">NephCure &#8211; PARASOL Grant Program<\/span><\/span><\/div>\n\n<div class=\"gb-container gb-container-80071c84 hero-copy\">\n\n<h1 class=\"gb-headline gb-headline-6cf43bd0 gb-headline-text hero-content\">NephCure &#8211; PARASOL Grant Program<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Due to a significant increase in the scope of the original project, NephCure now has limited funds available for additional grant support.<\/strong>\u00a0\u00a0<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This funding opportunity will be a limited competition program for invited applicants who have previously collaborated with or contributed to PARASOL.<\/p>\n\n<\/div>\n\n<div class=\"gb-container gb-container-bc714c72\">\n<div class=\"gb-container gb-container-b9043987 gb-container-default\">\n<div class=\"gb-container gb-container-ed52396b gb-container-default\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-08dc723e\">\n<div class=\"gb-grid-column gb-grid-column-9ac4bc49\"><div class=\"gb-container gb-container-9ac4bc49\">\n\n<figure class=\"gb-block-image gb-block-image-b652c693\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-b652c693\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"Headline decoration line\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-objectives\" style=\"font-size:25px\"><strong><strong>Objectives<\/strong><\/strong><\/h3>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\">NephCure in cooperation with the International Society of Glomerular Diseases, the Kidney Health Initiative, and the National Kidney Foundation continues to support a research grant program to support the PARASOL project.&nbsp;<a href=\"https:\/\/www.is-gd.org\/parasol\" target=\"_blank\" rel=\"noreferrer noopener\">PARASOL<\/a>&nbsp;is a collaborative international effort that aims to define the quantitative relationships between short-term changes in biomarkers (proteinuria and GFR) and long-term outcomes in order to support the use of alternative proteinuria-based endpoints as a basis for accelerated and traditional approval.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The PARASOL group is achieving these aims by conducting a large-scale analysis of existing data from patients of all ages with FSGS who have participated in observational cohort studies, completed clinical trials, regional or national registries, or real-world data sets.<\/p>\n\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-7cd2dee9\"><div class=\"gb-container gb-container-7cd2dee9\">\n\n<figure class=\"gb-block-image gb-block-image-f3469e34\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" class=\"gb-image gb-image-f3469e34\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2024\/03\/1-1-1024x576.png\" alt=\"\" title=\"kidney\" srcset=\"https:\/\/nephcure.org\/wp-content\/uploads\/2024\/03\/1-1-1024x576.png 1024w, https:\/\/nephcure.org\/wp-content\/uploads\/2024\/03\/1-1-300x169.png 300w, https:\/\/nephcure.org\/wp-content\/uploads\/2024\/03\/1-1-768x432.png 768w, https:\/\/nephcure.org\/wp-content\/uploads\/2024\/03\/1-1-1536x864.png 1536w, https:\/\/nephcure.org\/wp-content\/uploads\/2024\/03\/1-1-18x10.png 18w, https:\/\/nephcure.org\/wp-content\/uploads\/2024\/03\/1-1.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-3dd326cd gb-container-default\">\n\n<figure class=\"gb-block-image gb-block-image-f04b9551\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-f04b9551\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h3 class=\"gb-headline gb-headline-a237975b gb-headline-text\"><strong>Meritorious Characteristics<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Proposals will be evaluated for their compliance with the guiding principles described above. The following project characteristics will be considered meritorious if:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>The proposed project is willing and able contribute necessary and valuable data or statistical expertise to the PARASOL project to support achievement of PARASOL aims.<\/li>\n\n\n\n<li>The proposed project leads are able to meet the timelines established for PARASOL project success.<\/li>\n<\/ol>\n\n<\/div>\n\n<div class=\"gb-container gb-container-884e10b6 gb-container-default\">\n\n<figure class=\"gb-block-image gb-block-image-b9f96c05\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-b9f96c05\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h3 class=\"gb-headline gb-headline-c19d8fc6 gb-headline-text\"><strong>Eligibility<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">There are two programs supported under this announcement.<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>The clinician investigator program is open to all investigators or clinicians who oversee an existing cohort study, registry, or real-world data inclusive of substantial FSGS patient data meeting the dataset eligibility criteria defined by the PARASOL Data Analysis Team.<\/li>\n\n\n\n<li>The statistician program is open to individuals with key expertise in statistical planning and execution that will support the design and conduct of the statistical analysis necessary for this project.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Dataset Eligibility<\/strong><\/p>\n\n\n<div class=\"gb-container gb-container-62982561\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-7c722546\">\n<div class=\"gb-grid-column gb-grid-column-6d0b477a\"><div class=\"gb-container gb-container-6d0b477a\">\n\n<ol class=\"wp-block-list\">\n<li>Ability to define cohort based on eligibility criteria below<\/li>\n\n\n\n<li>Proteinuria and serum creatinine at biopsy\/diagnosis and longitudinally.<\/li>\n\n\n\n<li>Ascertainment of kidney failure and death per definitions above.<\/li>\n\n\n\n<li>At least 100 participants meeting inclusion criteria in Table 2 AND:\n<ul class=\"wp-block-list\">\n<li>\u226524 months of follow-up<\/li>\n\n\n\n<li>\u22653 UPCR measurements 6-24 months post-index UPCR (any)<\/li>\n\n\n\n<li>\u22653 eGFR measurements 6-24 months post-index UPCR in prior bullet<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n\n\n<div class=\"gb-container gb-container-2954350b gb-container-default\">\n\n<figure class=\"gb-block-image gb-block-image-be41aeda\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-be41aeda\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h3 class=\"gb-headline gb-headline-397c3df9 gb-headline-text\"><strong>Funding<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">NephCure will award funds in accordance with anticipated costs per project to support high quality dataset contributions and statistical leadership to PARASOL.\u00a0\u00a0To protect the integrity of the PARASOL study and ensure regulatory compliance, applying registries and individuals must be reviewed and approved by the PARASOL Organizing Committee before submission of a proposal for funding from NephCure.<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Projects will be funded directly by NephCure to the recipient institutions.<\/strong><\/li>\n\n\n\n<li><strong>Budget and justification<\/strong>\u00a0will be reviewed by the PARASOL Finance Committee in consultation with the PARASOL Organizing Committee and decision will be made regarding support needed to ensure high quality registry data is able to be contributed.<\/li>\n\n\n\n<li><strong>Funds will be provided to cover project direct costs only. No indirect costs.<\/strong>\u00a0NephCure has a long-standing policy to support direct costs only.<\/li>\n\n\n\n<li>The\u00a0<strong>number of projects funded<\/strong>\u00a0during will be dictated by the size of project budgets requested and awarded. NephCure makes this determination at the time of review.<\/li>\n<\/ol>\n\n<\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-e2864a44\"><div class=\"gb-container gb-container-e2864a44\">\n\n<figure class=\"wp-block-table alignright\"><table><tbody><tr><td><strong>Dataset-Required Criterion<\/strong><\/td><td><strong>Definition<\/strong><\/td><\/tr><tr><td>Biopsy-proven or monogenic FSGS<\/td><td><br>Documented description of adjudication of FSGS diagnosis<br><\/td><\/tr><tr><td>Index UPCR\u22651 g\/g (or equivalent g\/day)<\/td><td><br>At least one UPCR\u22651 g\/g at or after biopsy\/diagnosis (or up to 3 months prior to biopsy\/diagnosis)<br><\/td><\/tr><tr><td>Index eGFR\u226530 ml\/min\/1.73m<sup>2<\/sup><\/td><td><br>eGFR measurement must be within \u00b13 months from index UPCR<br><\/td><\/tr><tr><td>UPCR measurement 6-24 months after index date<\/td><td><br>\u22651 UPCR measurement 6-24 months after index UPCR<br><\/td><\/tr><tr><td>No evidence of kidney failure (see above definition) within 6 months<\/td><td><br>No kidney failure events prior to the first observed UPCR&gt;6 months post-index date<br><\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">*Note that data from all participants meeting inclusion criteria in Table 2 will be requested\/analyzed, however, at least 100 participants must meet the additional requirements above.<\/figcaption><\/figure>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-0746e55c gb-container-default\">\n\n<figure class=\"gb-block-image gb-block-image-a0d2cce4\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-a0d2cce4\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h3 class=\"gb-headline gb-headline-85518750 gb-headline-text\"><strong>Application\/Review Process<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><strong>The process of submitting applications to NephCure for this grant program occurs in 2 steps. No application can be submitted to NephCure before approval of\/invitation by the PARASOL Organizing Committee, which assesses proposals for feasibility.\u00a0<\/strong><\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>PARASOL Organizing Committee Approval: The investigator meets with the PARASOL intake team to discuss PARASOL objectives and alignment and feasibility of including the proposed registry\/dataset. An assessment of contributing registry\/dataset value is provided to the PARASOL Organizing Committee. Approval and invitation to submit is necessary prior to submission for funding.<\/li>\n\n\n\n<li>Grant Submission to NephCure: Once the PARASOL Organizing Committee approves the proposed registry\/dataset, the investigator will be invited to submit a grant proposal to NephCure utilizing the application template provided. NephCure, in conjunction with the PARASOL grant review committee, is responsible for funding decisions.<\/li>\n<\/ol>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Deadline: \u00a0There is no formal deadline for the application and applications are reviewed on a rolling basis.<\/strong> Applicants may discuss the application process with Dr. Laura Mariani\u00a0<a href=\"mailto:lmariani@med.umich.edu\">lmariani@med.umich.edu<\/a> prior to making an application.<\/p>\n\n<\/div>\n\n<div class=\"gb-container gb-container-62e83871 gb-container-default\">\n\n<figure class=\"gb-block-image gb-block-image-d7ffb46c\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-d7ffb46c\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h3 class=\"gb-headline gb-headline-c607456e gb-headline-text\"><strong>Application Format<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Please complete and submit using the <a href=\"https:\/\/nephcure.org\/wp-content\/uploads\/2024\/04\/PARASOL-NephCure_GrantApplication.docx\" target=\"_blank\" rel=\"noreferrer noopener\">PARASOL grant application template.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Terms of Support<\/strong><strong>&nbsp;<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Funds (direct costs only) are provided to investigator\u2019s institution for use by the applicant; it is the applicant institution\u2019s obligation to ensure proper use of funds and timely submission of progress reports. Funds will be provided to cover project direct costs only. No indirect costs. NephCure has a long-standing policy to support direct costs only.<\/li>\n\n\n\n<li>Disbursal of grant funds will be made in 2 payments. 50% of payment will be made upon notice of award and remaining 50% will be paid following either receipt of registry data in format established by PARASOL Data Analysis Committee or confirmation by the PARASOL Data Analysis Committee of active participation and substantial committee to statistical planning.&nbsp;<\/li>\n\n\n\n<li>Principal investigators must comply with human institutional review board requirements and demonstrate current approval of these committees.<\/li>\n\n\n\n<li>It is expected that data provided to the coordinating center will be shared in a de-identified manner with contributing registries within PARASOL.<\/li>\n\n\n\n<li>It is expected that publications will be submitted in compliance with the publications policies of PARASOL.<\/li>\n\n\n\n<li>NephCure support will be acknowledged by grantees in publications, presentations, abstracts, and other relevant press releases and on associated websites.<\/li>\n\n\n\n<li>NephCure does not discriminate on the basis of race, gender, religious, or ethnic group; applicants should assure compliance with this policy in designing and executing their studies.<\/li>\n<\/ul>\n\n<\/div>\n<\/section>\n\n<div class=\"gb-container gb-container-42105b23 news-letter-sec alignfull\">\n\n<figure class=\"gb-block-image gb-block-image-b3f3ccb8\"><img loading=\"lazy\" decoding=\"async\" width=\"1920\" height=\"120\" class=\"gb-image gb-image-b3f3ccb8\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/purple-curve.svg\" alt=\"\" title=\"purple-curve\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-41717e70 alignwide\">\n\n<h2 class=\"gb-headline gb-headline-1760ac29 gb-headline-text\">Sign up to get NephCure\u2019s latest updates.<\/h2>\n\n\n\n<a class=\"gb-button gb-button-753f318a gb-button-text gb-button-primary button\" href=\"\/newsletter\/\">SIGN UP<\/a>\n\n\n<div class=\"gb-container gb-container-2b968bcb news-letter-field\">\n    <script type=\"text\/javascript\">\n    jQuery(document).ready(function($) {\n        const disposableDomains = [\n            'mailinator.com', 'yopmail.com', 'tempmail.com', 'guerrillamail.com',\n            'throwawaymail.com', 'fakeinbox.com', 'trashmail.com', 'sharklasers.com',\n            'tempinbox.com', '10minutemail.com'\n        ];\n        const majorProviders = [\n            'gmail.com', 'yahoo.com', 'hotmail.com', 'outlook.com',\n            'aol.com', 'icloud.com', 'protonmail.com'\n        ];\n        const suspiciousUsernames = [\n            'test', 'example', 'user', 'admin', 'info', 'mail', 'email',\n            'noreply', 'no-reply', 'donotreply', 'do-not-reply', 'fake',\n            'abc', '123', 'xyz', 'asdf', 'qwerty', 'demo', 'sample',\n            'spam', 'temp', 'dummy', 'foobar', 'anonymous', 'disposable'\n        ];\n        const keyboardPatterns = ['qwerty', 'asdfgh', 'zxcvbn', '123456'];\n\n        function isValidEmailFormat(email) {\n            const regex = \/^[^\\s@]+@[^\\s@]+\\.[^\\s@]+$\/;\n            return regex.test(email);\n        }\n\n        function hasSuspiciousPattern(username) {\n            if (suspiciousUsernames.includes(username)) return true;\n            if (username.length <= 2) return true;\n            if (\/^(.)\\1{3,}$\/.test(username)) return true;\n            for (const pattern of keyboardPatterns) {\n                if (username.includes(pattern)) return true;\n            }\n            return false;\n        }\n\n        function usernameMatchesDomain(username, domain) {\n            const domainBase = domain.split('.')[0];\n            return username === domainBase;\n        }\n\n        $('.ginput_container_email input').on('blur', function() {\n            const emailField = $(this);\n            const email = emailField.val().trim().toLowerCase();\n            const errorContainer = emailField.siblings('.validation_message');\n\n            \/\/ Clear any previous messages\n            if (errorContainer.length) errorContainer.remove();\n            emailField.removeClass('gfield_error gfield_warning');\n\n            if (email === '') return;\n\n            const username = email.substring(0, email.lastIndexOf('@'));\n            const domain = email.substring(email.lastIndexOf('@') + 1);\n\n            if (!isValidEmailFormat(email)) {\n                emailField.after('<div class=\"validation_message\">Please enter a valid email address.<\/div>');\n                emailField.addClass('gfield_error');\n                return;\n            }\n\n            if (disposableDomains.includes(domain)) {\n                emailField.after('<div class=\"validation_message\">Disposable email addresses are not allowed.<\/div>');\n                emailField.addClass('gfield_error');\n                return;\n            }\n\n            if (usernameMatchesDomain(username, domain)) {\n                emailField.after('<div class=\"validation_message\">This email looks suspicious (username matches domain). 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