{"id":25774,"date":"2024-01-31T09:40:20","date_gmt":"2024-01-31T14:40:20","guid":{"rendered":"https:\/\/nephcure.org\/?page_id=25774"},"modified":"2024-04-25T22:08:25","modified_gmt":"2024-04-26T02:08:25","slug":"ciclofosfamida","status":"publish","type":"page","link":"https:\/\/nephcure.org\/es\/managing-rkd\/treatment-options\/cyclophosphamide\/","title":{"rendered":"ciclofosfamida"},"content":{"rendered":"<section class=\"gb-container gb-container-ba2e2dcb\">\n<div class=\"yoast-breadcrumbs breadcrumb\"><span><span><a href=\"https:\/\/nephcure.org\/\">Home<\/a><\/span> \/ <span><a href=\"https:\/\/nephcure.org\/managing-rkd\/\">Managing RKD<\/a><\/span> \/ <span><a href=\"https:\/\/nephcure.org\/managing-rkd\/treatment-options\/\">Treatment Options<\/a><\/span> \/ <span class=\"breadcrumb_last\" aria-current=\"page\">Cyclophosphamide<\/span><\/span><\/div>\n\n<div class=\"gb-container gb-container-80071c84 hero-copy\">\n\n<h1 class=\"gb-headline gb-headline-6cf43bd0 gb-headline-text hero-content\">Cyclophosphamide<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Cyclophosphamide (brand name: Cytoxan) is a medication that lowers the body\u2019s natural immunity. The immune system is thought to be involved in causing nephrotic syndrome. By lowering the immune system\u2019s activity, this treatment may help patients suffering from nephrotic syndrome. However, it may take several weeks for cyclophosphamide to make a difference.<\/p>\n\n<\/div>\n<\/section>\n\n<div class=\"gb-container gb-container-a6126eda\">\n\n<figure class=\"gb-block-image gb-block-image-40625f55\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-40625f55\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-88096344 gb-headline-text\">Why is Cyclophosphamide Needed for Rare Kidney Disease Patients?<\/h2>\n\n\n\n<p class=\"gb-headline gb-headline-fb79fb92 gb-headline-text\">If too many relapses are occurring, a doctor may prescribe Cyclophosphamide. A doctor may recommend this treatment if nephrotic syndrome doesn\u2019t get better with steroid treatment or if it keeps coming back. Usual dosage time is 8\u201312 weeks. It should help symptoms to improve and help people to go into or stay in remission.<\/p>\n\n\n<div class=\"gb-container gb-container-626eb763\"><\/div>\n\n\n<figure class=\"gb-block-image gb-block-image-d19c326c\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-d19c326c\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-3de92b95 gb-headline-text\">How is Cyclophosphamide Administered?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Cyclophosphamide is available in tablet or liquid form.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cyclophosphamide is usually given once a day, usually in the morning to reduce the chance of developing bladder problems. The medication should be given at about the same time(s) every day so that this becomes part of a daily routine, which also helps patients to remember to take it.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The doctor will determine the correct dose of Cyclophosphamide. A simple urine and blood test will be performed to make sure the dose is correct.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tablets should be taken with a glass of water, milk, or juice. Tablets should not be chewed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If taking the liquid form, measure the correct amount using an oral syringe or medicine spoon. (You can get these from your pharmacist.) Do not use a kitchen teaspoon because you will not be able to measure out the correct amount.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>*Note: The decision to prescribe a medication is the responsibility of your physician\/primary care provider based on his\/her evaluation of your condition. The above is meant for informational purposes only. Discuss this information and all information about drugs\/medications with your physician before starting or stopping any medication.<\/em><\/p>\n\n<\/div>\n\n<div class=\"gb-container gb-container-80f48e60\">\n\n<figure class=\"gb-block-image gb-block-image-34ab1ee5\"><img loading=\"lazy\" decoding=\"async\" width=\"54\" height=\"4\" class=\"gb-image gb-image-34ab1ee5\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/heading-line.svg\" alt=\"\" title=\"heading-line\"\/><\/figure>\n\n\n\n<h2 class=\"gb-headline gb-headline-bff6dfde gb-headline-text\">Frequently Asked Questions<\/h2>\n\n\n<div class=\"gb-container gb-container-3f003111 gb-accordion\">\n<div class=\"gb-container gb-container-342c972d gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-05b57231 gb-accordion__toggle\"><span class=\"gb-button-text\">What are the possible side effects of Cyclophosphamide?<\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" width=\"1em\" height=\"1em\" ariahidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" width=\"1em\" height=\"1em\" ariahidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div class=\"gb-accordion__content\"><div class=\"gb-container gb-container-f9fdcd74\">\n\n<p class=\"wp-block-paragraph\">Some people may develop some common side effects while taking Cyclophosphamide. Check with your doctor if any of these side effects will not go away or become bothersome:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Upset stomach<\/li>\n\n\n\n<li>Vomiting<\/li>\n\n\n\n<li>Flushing (face turning red and warm)<\/li>\n\n\n\n<li>Stuffy nose, headache, pain across the cheekbones<\/li>\n\n\n\n<li>Darkening of the skin and fingernails<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Immediately consult a doctor if you notice any of these side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Unusual tiredness or weakness<\/li>\n\n\n\n<li>Uncontrolled diarrhea<\/li>\n\n\n\n<li>Sores on the lips, tongue, mouth, or throat<\/li>\n\n\n\n<li>Missing monthly menstrual periods<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">After stopping cyclophosphamide, some side effects may still continue. Check with your doctor right away if there is blood in your urine, especially after stopping Cyclophosphamide.<\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-2fcf7640 gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-69efb835 gb-accordion__toggle\"><span class=\"gb-button-text\">What are precautionary measures to take while taking Cyclophosphamide?<\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" width=\"1em\" height=\"1em\" ariahidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" width=\"1em\" height=\"1em\" ariahidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div class=\"gb-accordion__content\"><div class=\"gb-container gb-container-7a4bb49d\">\n\n<p class=\"wp-block-paragraph\">Cyclophosphamide may lower the number of white blood cells in the blood, which increases the chances of infection. A blood test will be done every week to make sure that these white blood cells don\u2019t decrease too much. The dose may need to be lowered or temporarily stopped if the white blood cells decrease too much. Your doctor will notify you if any change is required in the dose of the drug.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Watch closely for signs of infection, such as a fever, chills, cough, and sore throat. Contact a doctor immediately if you notice any signs of infection.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cyclophosphamide can lower the number of platelets in the blood, which means bleeding may occur more easily. To prevent bleeding:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Be careful when using a razor, scissors, or clippers to cut nails or hair.<\/li>\n\n\n\n<li>Do not engage in rough sports where there is a chance that bruising or injury may occur.<\/li>\n\n\n\n<li>Be careful when using a toothbrush, dental floss, or toothpick. <\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">No immunizations (vaccines) should be given without the doctor\u2019s approval.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If blood levels of cyclophosphamide are too high, kidney function may decrease. This is why blood work is done frequently so that the dose of cyclophosphamide can be adjusted.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Your doctor may want the bladder emptied every two hours and may also want the bladder emptied during the night. This helps prevent problems with the bladder and kidneys.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Avoid grapefruit and grapefruit juice when taking Cyclophosphamide. These increase the amount of Cyclophosphamide in the blood, which may cause more side effects.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cyclophosphamide may cause birth defects. If you are pregnant or there is a possibility that you may become pregnant, tell your doctor right away.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Check with your doctor before taking any other medicines (prescription, non-prescription, herbal, or natural products). Before having any operation or procedure, inform your doctor or dentist that you are taking cyclophosphamide.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hair loss may occur, but this is rare at the dosage levels used to treat nephrotic syndrome. If hair loss does occur, the hair will grow back when treatment with cyclophosphamide stops, but the color and texture may change when it does.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><em>*Note: The decision to prescribe a medication is the responsibility of your physician\/primary care provider based on his\/her evaluation of your condition. The above is meant for informational purposes only. Discuss this information and all information about drugs\/medications with your physician before starting or stopping any medication.<\/em><\/p>\n\n<\/div><\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-68f0eaa5 gb-accordion__item\" data-transition=\"slide\">\n\n<button class=\"gb-button gb-button-d702eeea gb-accordion__toggle\"><span class=\"gb-button-text\">What are possible side effects aren&#8217;t common?<\/span><span class=\"gb-icon\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" width=\"1em\" height=\"1em\" ariahidden=\"true\" role=\"img\" class=\"gb-accordion__icon\"><path d=\"M416 208H272V64c0-17.67-14.33-32-32-32h-32c-17.67 0-32 14.33-32 32v144H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h144v144c0 17.67 14.33 32 32 32h32c17.67 0 32-14.33 32-32V304h144c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\" fill=\"currentColor\"><\/path><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 448 512\" width=\"1em\" height=\"1em\" ariahidden=\"true\" role=\"img\" class=\"gb-accordion__icon-open\"><path d=\"M416 208H32c-17.67 0-32 14.33-32 32v32c0 17.67 14.33 32 32 32h384c17.67 0 32-14.33 32-32v-32c0-17.67-14.33-32-32-32z\" fill=\"currentColor\"><\/path><\/svg><\/span><\/button>\n\n\n<div class=\"gb-accordion__content\"><div class=\"gb-container gb-container-2b8161d3\">\n\n<p class=\"wp-block-paragraph\">The following side effects are not common, so they may be a sign of a serious problem. Call your doctor immediately or go to the emergency room if you experience these side effects:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>&nbsp; &nbsp; Fever or chills<\/li>\n\n\n\n<li>&nbsp; &nbsp; Cough or sore throat<\/li>\n\n\n\n<li>&nbsp; &nbsp; Unusual bleeding or bruising<\/li>\n\n\n\n<li>&nbsp; &nbsp; Burning feeling or pain when urinating<\/li>\n\n\n\n<li>&nbsp; &nbsp; Pain in the lower back or side<\/li>\n\n\n\n<li>&nbsp; &nbsp; Blood in the urine or in the stool<\/li>\n\n\n\n<li>&nbsp; &nbsp; Black, tarry stools<\/li>\n\n\n\n<li>&nbsp; &nbsp;&nbsp;Trouble breathing or shortness of breath<\/li>\n\n\n\n<li>&nbsp; &nbsp; Fast heartbeat<\/li>\n\n\n\n<li>&nbsp; &nbsp; Dizziness, confusion, or agitation<\/li>\n\n\n\n<li>&nbsp; &nbsp; Yellow eyes or skin<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">After stopping cyclophosphamide, some side effects may still continue. Check with your doctor right away if there is blood in your urine, especially after stopping cyclophosphamide.<\/p>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-0d21e4ac\">\n<div class=\"gb-grid-wrapper gb-grid-wrapper-3d338a55\">\n<div class=\"gb-grid-column gb-grid-column-296a2c84\"><div class=\"gb-container gb-container-296a2c84\">\n<div class=\"gb-container gb-container-eb83049f\">\n\n<h2 class=\"gb-headline gb-headline-5127a4de gb-headline-text\">Find a Specialist<\/h2>\n\n\n\n<p class=\"gb-headline gb-headline-00d5119d gb-headline-text\">It is important to work with a nephrologist who specializes in rare kidney disease (RKD) and can provide personalized advice based on your individual health needs and changes in available treatments. NephCure has a curated list of NephCure Specialists nationwide ready to help you.<\/p>\n\n<\/div>\n\n<div class=\"gb-container gb-container-54aa31c0\"><a class=\"gb-container-link\" href=\"https:\/\/nephcure.org\/managing-rkd\/find-a-specialist\/\"><\/a>\n\n<p class=\"gb-headline gb-headline-38137575\"><span class=\"gb-icon\"><svg fill=\"none\" viewBox=\"0 0 27 24\" height=\"24\" width=\"27\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"> <path fill=\"#00556B\" d=\"M26.0607 13.0607C26.6464 12.4749 26.6464 11.5251 26.0607 10.9393L16.5147 1.3934C15.9289 0.807611 14.9792 0.807611 14.3934 1.3934C13.8076 1.97919 13.8076 2.92893 14.3934 3.51472L22.8787 12L14.3934 20.4853C13.8076 21.0711 13.8076 22.0208 14.3934 22.6066C14.9792 23.1924 15.9289 23.1924 16.5147 22.6066L26.0607 13.0607ZM0 13.5H25V10.5H0V13.5Z\"><\/path> <\/svg><\/span><\/p>\n\n<\/div>\n<\/div><\/div>\n\n<div class=\"gb-grid-column gb-grid-column-00512214\"><div class=\"gb-container gb-container-00512214\">\n<div class=\"gb-container gb-container-178632bb\">\n\n<h2 class=\"gb-headline gb-headline-74b009b0 gb-headline-text\">Clinical Trials<\/h2>\n\n\n\n<p class=\"has-secondary-lighter-gray-color has-text-color has-link-color wp-elements-6bb4aec7a7f561f2b664a676c9d49fc4 wp-block-paragraph\">From accessing cutting-edge treatments to being part of groundbreaking research, discover the benefits that can make a real difference. Learn more about clinical trials currently taking place, and find opportunities near you.<\/p>\n\n<\/div>\n\n<div class=\"gb-container gb-container-e263f928\"><a class=\"gb-container-link\" href=\"https:\/\/nephcure.org\/managing-rkd\/clinical-trials\/\"><\/a>\n\n<p class=\"gb-headline gb-headline-7dbd95e4\"><span class=\"gb-icon\"><svg fill=\"none\" viewBox=\"0 0 27 24\" height=\"24\" width=\"27\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"> <path fill=\"#00556B\" d=\"M26.0607 13.0607C26.6464 12.4749 26.6464 11.5251 26.0607 10.9393L16.5147 1.3934C15.9289 0.807611 14.9792 0.807611 14.3934 1.3934C13.8076 1.97919 13.8076 2.92893 14.3934 3.51472L22.8787 12L14.3934 20.4853C13.8076 21.0711 13.8076 22.0208 14.3934 22.6066C14.9792 23.1924 15.9289 23.1924 16.5147 22.6066L26.0607 13.0607ZM0 13.5H25V10.5H0V13.5Z\"><\/path> <\/svg><\/span><\/p>\n\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<div class=\"gb-container gb-container-42105b23 news-letter-sec alignfull\">\n\n<figure class=\"gb-block-image gb-block-image-b3f3ccb8\"><img loading=\"lazy\" decoding=\"async\" width=\"1920\" height=\"120\" class=\"gb-image gb-image-b3f3ccb8\" src=\"https:\/\/nephcure.org\/wp-content\/uploads\/2023\/11\/purple-curve.svg\" alt=\"\" title=\"purple-curve\"\/><\/figure>\n\n\n<div class=\"gb-container gb-container-41717e70 alignwide\">\n\n<h2 class=\"gb-headline gb-headline-1760ac29 gb-headline-text\">Sign up to get NephCure\u2019s latest updates.<\/h2>\n\n\n\n<a class=\"gb-button gb-button-753f318a gb-button-text gb-button-primary button\" href=\"\/newsletter\/\">SIGN UP<\/a>\n\n\n<div class=\"gb-container gb-container-2b968bcb news-letter-field\">\n    <script type=\"text\/javascript\">\n    jQuery(document).ready(function($) {\n        const disposableDomains = [\n            'mailinator.com', 'yopmail.com', 'tempmail.com', 'guerrillamail.com',\n            'throwawaymail.com', 'fakeinbox.com', 'trashmail.com', 'sharklasers.com',\n            'tempinbox.com', '10minutemail.com'\n        ];\n        const majorProviders = [\n            'gmail.com', 'yahoo.com', 'hotmail.com', 'outlook.com',\n            'aol.com', 'icloud.com', 'protonmail.com'\n        ];\n        const suspiciousUsernames = [\n            'test', 'example', 'user', 'admin', 'info', 'mail', 'email',\n            'noreply', 'no-reply', 'donotreply', 'do-not-reply', 'fake',\n            'abc', '123', 'xyz', 'asdf', 'qwerty', 'demo', 'sample',\n            'spam', 'temp', 'dummy', 'foobar', 'anonymous', 'disposable'\n        ];\n        const keyboardPatterns = ['qwerty', 'asdfgh', 'zxcvbn', '123456'];\n\n        function isValidEmailFormat(email) {\n            const regex = \/^[^\\s@]+@[^\\s@]+\\.[^\\s@]+$\/;\n            return regex.test(email);\n        }\n\n        function hasSuspiciousPattern(username) {\n            if (suspiciousUsernames.includes(username)) return true;\n            if (username.length <= 2) return true;\n            if (\/^(.)\\1{3,}$\/.test(username)) return true;\n            for (const pattern of keyboardPatterns) {\n                if (username.includes(pattern)) return true;\n            }\n            return false;\n        }\n\n        function usernameMatchesDomain(username, domain) {\n            const domainBase = domain.split('.')[0];\n            return username === domainBase;\n        }\n\n        $('.ginput_container_email input').on('blur', function() {\n            const emailField = $(this);\n            const email = emailField.val().trim().toLowerCase();\n            const errorContainer = emailField.siblings('.validation_message');\n\n            \/\/ Clear any previous messages\n            if (errorContainer.length) errorContainer.remove();\n            emailField.removeClass('gfield_error gfield_warning');\n\n            if (email === '') return;\n\n            const username = email.substring(0, email.lastIndexOf('@'));\n            const domain = email.substring(email.lastIndexOf('@') + 1);\n\n            if (!isValidEmailFormat(email)) {\n                emailField.after('<div class=\"validation_message\">Please enter a valid email address.<\/div>');\n                emailField.addClass('gfield_error');\n                return;\n            }\n\n            if (disposableDomains.includes(domain)) {\n                emailField.after('<div class=\"validation_message\">Disposable email addresses are not allowed.<\/div>');\n                emailField.addClass('gfield_error');\n                return;\n            }\n\n            if (usernameMatchesDomain(username, domain)) {\n                emailField.after('<div class=\"validation_message\">This email looks suspicious (username matches domain). 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Se cree que el sistema inmunol\u00f3gico participa en la causa del s\u00edndrome nefr\u00f3tico. 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