Scientific Advisory Board

Lawrence Holzman, M.D., Ph.D.
Chair of the NephCure SAB

University of Pennsylvania

Chief, Renal Electrolyte and Hypertension Division
Professor of Medicine

3400 Spruce Street

Philadelphia, PA 19104

Phone: 215-573-1831

Fax: 215-898-0891
Email: lholzman@mail.med.upenn.edu

Dr. Lawrence Holzman is the Chairman of the NephCure Advisory Board. Dr. Holzman is a Professor at the University of Pennsylvania, Chief, Renal Electrolyte and Hypertension Division. He is affiliated with numerous Professional Organizational Fellowships, including the American Society of Nephrologists, the American Heart Association Kidney Council, the American Association for the Advancement of Science, and the National Kidney Foundation Science Committee.

Dr. Holzman received his M.D. training from the New Jersey Medical School. After completing his residency at The Hospital of the Medical College of Pennsylvania, he went on to complete his fellowship in Nephrology at the University of Michigan. Dr. Holzman’s research is primarily focused in two crucial areas: the area of stress activated protein kinase signaling and the cell biology of the podocyte. Dr. Holzman has served as a research mentor to several fellows who have gone on to achieve academic positions in the United States and Germany. His laboratory has become paramount in the field and his research has led to multiple discoveries, some of which have been exemplary for work in other subjects.

His clinical interests include glomerular disease with particular interest in lupus nephritis, systemic vasculitis, and other inflammatory glomerulonephritidities. Dr. Holzman is credited with several publications concerning Nephrology and other related areas. He is recognized by many as a gifted doctor, teacher, and mentor.

Selected Publications:

Garg, Puneet, Verma, R., Nihalani, D, Holzman, LB. Nephrin and Neph1 form a signaling complex and cooperate to regulate actin polymerization. Mol Cell Biol. 2007 Dec;27(24):8698-712. Epub 2007 Oct 8.

Braun GS, Kretzler M, Heider T, Floege J, Holzman LB, Kriz W, Moeller MJ Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cells. J Biol Chem. 2007 Aug 3;282(31):22823-33. Epub 2007 May 11.

Harvey SJ, George Jarad, Jeanette Cunningham, Angelique L. Rops, Johan van der Vlag, Jo H. Berden, Marcus J. Moeller, Lawrence B. Holzman, Robert W. Burgess , and Jeffrey H. Miner. Disruption of Glomerular Basement Memebrane Charge Through Podocyte-Specific Mutation of Agrin Does Not Alter Glomerular Permselectivity. Am J Pathol. 2007 Jul;171(1):139-52.